Results 91 to 100 of about 201,245 (267)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
ON NULL CURVES ON SURFACES AND NULL VECTORS IN LORENTZ SPACE
Süleyman Demirel Üniversitesi Fen-Edebiyat Fakültesi Fen Dergisi, 2009 : In this work, we compare the Darboux frame and the Frenet frame of a null curve lying on a spacelike surface in the three-dimensional Lorentz space, and we show that the normal curvature of the curve is a constant.
A. Ceylan ÇÖKEN
doaj
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Geometriae Dedicata, 2001 We show that the number of simple closed geodesics of length bounded by L on a hyperbolic surface of genus g with c cusps and b boundary components grows roughly like L^{6g+2b+2c-6}. This has been conjectured for some time.
openaire +2 more sources
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Distance-Normal Congruence of Rotational Surfaces in Euclidean 3-Space
Journal of MathematicsIn this study, we considered simple linear congruences of some curves/surfaces to generate parametric families of curves/surfaces. The method depends essentially on the position vector of a curve/surface and its signed unit normal.
Betül Bulca Sokur
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Comparison of nonlinear curves and surfaces. [PDF]
Comput Stat Data Anal, 2020 Zhao S, Bakoyannis G, Lourens S, Tu W.
europepmc +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source