Results 81 to 90 of about 201,245 (267)

Sweeping Surfaces of Polynomial Curves in Euclidean 3-space

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica
In this study, we investigate the surfaces created by the movement of the profile curves through the regular polynomial spine curves. To overcome the restrictions of establishing a frame of the polynomial curves at the points where the second and higher ...
Zhu Yuting, Li Yanlin, Eren Kemal, Ersoy Soley   +3 more
doaj   +1 more source

Geometric properties of Smarandache ruled surfaces generated by integral binormal curves in Euclidean 3-space

Partial Differential Equations in Applied Mathematics
This paper investigates the geometric properties of Smarandache ruled surfaces generated by integral binormal curves in the Euclidean 3-space E3. Specifically, we study four types of Smarandache ruled surfaces: the tn, tb, nb, and tnb surfaces, each ...
Ayman Elsharkawy, Hanene Hamdani, Clemente Cesarano, Noha Elsharkawy   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Rational cuspidal curves with four cusps on Hirzebruch surfaces

Le Matematiche, 2014
The purpose of this article is to shed light on the question of how many and what kind of cusps a rational cuspidal curve on a Hirzebruch surface can have.
Torgunn Karoline Moe
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Geometry of generated quasi-ruled surfaces from their quasi-parallel curves according to the q-frame in R3

Frontiers in Physics
Parallel curves have been used extensively in a variety of fields during the last decade, including architecture, computer graphics, aerospace, and medicine.
Samah Gaber, Entesar Eliwa, Fatimah Almujhim, Salma Alfadhel, Maram Almusayyib   +4 more
doaj   +1 more source

Biharmonic curves on a surface.

Rendiconti di Matematica e delle Sue Applicazioni, 2001
Biharmonic curves in a manifold are (real) curves that minimize the \(L^2\)-norm of the tension field. Since the tension field of a geodesic in parametrization by arclength vanishes, geodesics are biharmonic curves. But there can be biharmonic curves which are nongeodesic, and the paper is concerned with nongeodesic biharmonic curves in surfaces.
CADDEO, RENZO ILARIO, MONTALDO, STEFANO, PIU, MARIA PAOLA   +2 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source