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Cushing’s disease, or pituitary ACTH dependent Cushing’s syndrome, is a rare disease responsible for increased morbidity and mortality. Signs and symptoms of hypercortisolism are usually non specific: obesity, signs of protein wasting, increased blood ...
Castinetti Frederic +3 more
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In patients with Cushing’s disease (CD), prompt diagnosis and treatment are essential for favorable long-term outcomes, although this remains a challenging task. The differential diagnosis of CD is still difficult in some patients, even with an organized stepwise diagnostic approach.
Nishioka, Hiroshi, Yamada, Shozo
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Comorbidities in Cushing’s disease [PDF]
Cushing's disease is a rare disorder characterized by overproduction of ACTH from a pituitary adenoma leading to hypercortisolemia that in turn leads to increased morbidity and mortality.Here we review the comorbidities associated with Cushing's disease and their impact on quality of life and mortality.Recent evidence suggests that correction of ...
Sharma, ST, Nieman, LK, Feelders, R.A.
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The Treatment of Cushing's Disease [PDF]
AbstractCushing's disease (CD), or pituitary-dependent Cushing's syndrome, is a severe endocrine disease caused by a corticotroph pituitary tumor and associated with increased morbidity and mortality. The first-line treatment for CD is pituitary surgery, which is followed by disease remission in around 78% and relapse in around 13% of patients during ...
PIVONELLO, ROSARIO +3 more
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Clinical periodontal diagnosis
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi +5 more
wiley +1 more source
We report here a pediatric patient whose Cushing's Disease was diagnosed late because of her cyclical presentation, presumably due to subclinical pituitary apoplexy.
Sara H. Rahman +5 more
doaj +1 more source
INTRODUCTION[|]The purpose of this study is to assess the efficiency of inferior petrosal sinus sampling (IPSS) in the diagnosis of adrenocorticotropic hormone-dependent Cushing's disease and to compare it with magnetic resonance imaging (MRI).[¤]METHODS[
Tumay Bekci +5 more
doaj +1 more source
Mortality in Cushing’s Disease [PDF]
The causes of premature death in untreated Cushing’s syndrome are vascular disease (myocardial infarction/stroke), uncontrolled diabetes mellitus and complications and infections. Long-term mortality outcome studies on pituitary-dependent Cushing’s disease (CD) are limited to six studies in the English language literature.
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Objective: This study investigated the influence of ectopic and pituitary Cushing’s syndrome, diagnosed by sampling the inferior petrosal sinus and cavernous sinus, on comorbidities and clinical complications. Methods: Medical records of patients with
Zehra Kara +3 more
doaj +1 more source
Cushing's Disease in Children: Report of Three Cases
Cushing's disease is rare in children and adolescents. We report the clinical presentations of three children with Cushing's disease. All three exhibited the typical symptoms and signs of weight gain and growth retardation.
Ping-Yi Hsu +6 more
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