Results 1 to 10 of about 1,175,648 (153)
The Lancet, 2006 Cushing's syndrome results from lengthy and inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality. The syndrome remains a challenge to diagnose and manage. Here, we review the current understanding of pathogenesis, clinical features, diagnostic, and differential diagnostic approaches.
Newell-Price, J +3 more
openaire +4 more sources
Medicine, 2005 Abstract Harvey Cushing described the first case of Cushing’s syndrome with a severe phenotype in 1912. Since that time, investigation and management of Cushing’s syndrome has remained a significant clinical challenge and patients suspected of this diagnosis warrant referral to major centres.
openaire +2 more sources
The effect of sodium valproate in Cushing's disease, Nelson's syndrome and Addison's disease [PDF]
, 1988 We investigated the effect of sodium valproate on plasma ACTH and serum cortisol concentrations in different pathological states of ACTH hypersecretion.
Winkelmann, W. +4 more
core +1 more source
Clinical periodontal diagnosis
Periodontology 2000, EarlyView., 2023 Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi +5 more
wiley +1 more source
Nature Reviews Disease PrimersCushing syndrome (CS) is a constellation of signs and symptoms caused by excessive exposure to exogenous or endogenous glucocorticoid hormones. Endogenous CS is caused by increased cortisol production by one or both adrenal glands (adrenal CS) or by elevated adrenocorticotropic hormone (ACTH) secretion from a pituitary tumour (Cushing disease (CD)) or ...
Lynnette K. Nieman +6 more
openaire +4 more sources
Epidemiology of Cushing’s Syndrome [PDF]
Neuroendocrinology, 2010 Overt Cushing’s syndrome is a rare disorder with an annual incidence of 2–3/million of which benign adrenal adenomas account for 0.6/million. The female:male ratio is 3:1. Preliminary data indicate a high proportion of subclinical Cushing’s syndrome in certain risk populations such as patients with type 2 diabetes or osteoporosis.
Steffensen, Charlotte +3 more
openaire +3 more sources
Cushing syndrome: update on testing
, 2015 Endogenous hypercortisolism (Cushing syndrome) is one of the most enigmatic diseases in clinical medicine. The diagnosis and differential diagnosis of Cushing syndrome depend on proper laboratory evaluation.
Raff, Hershel
core +1 more source
Genetics of Cushing’s Syndrome [PDF]
Neuroendocrinology, 2010 Cushing’s syndrome (CS) is characterized by pathologically elevated free glucocorticoid levels. Endogenous hypercortisolism is usually due to ACTH-secreting pituitary corticotropic adenomas and less often due to ectopic ACTH-secreting neuroendocrine neoplasms or ACTH-independent adrenal cortisol hypersecretion.
Yaneva, M. +4 more
openaire +3 more sources
Coagulopathy in Cushing’s Syndrome [PDF]
Neuroendocrinology, 2010 A hypercoagulable state and its consequent increased incidence of thromboembolic complications are reported in patients with Cushing’s syndrome (CS). These alterations are related to cortisol excess that induces prothrombotic changes in blood by several and complex mechanisms including increased levels of clotting factors, mainly factor VIII and von ...
TREMENTINO L +6 more
openaire +3 more sources
Level of knowledge of medical students about Cushing´s Syndrome
, 2021 Introducción: el síndrome de Cushing es un conjunto de signos y síntomas de diverso origen que traducen la exposición de los tejidos a un exceso crónico de cortisol.
Carballido-Sánchez, Juan Pablo +3 more
core +1 more source