Results 41 to 50 of about 30,434 (264)
Empirical model of the Earth's cusp at low-altitudes
地球与行星物理论评, 2023 The Earth's cusp is a critical "window" for the solar wind plasma to enterthe low-altitude magnetosphere and ionosphere. However, the overall configuration of cusp has not been established.
Ziqian Liu +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Journal of the Mathematical Society of Japan, 2019 Let f_t , where t is close to zero, be an analytic family of plane-to-plane mappings. There are presented effective methods of computing the number of cusps of f_t emanating from the origin and having positive/negative cusp degree.
openaire +4 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Australian Generation Z and the Nexus between Climate Change and Alternative Proteins
Animals, 2022 Scientific evidence shows that current food systems are impacting the planet in ways that are unsustainable and detrimental to human health. Various technological advances have been made in response, one of them being the development of new food products
Diana Bogueva, Dora Marinova
doaj +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
DE-1 versus Cluster spectral density observations: the effect on ion outflow above the polar cap
Annals of Geophysics, 2015 Wave-particle interaction is a very important mechanism in describing the outflow of ions at high latitudes and high altitudes. Quasi-linear perpendicular velocity diffusion coefficients are used to describe the effect of wave-particle interactions ...
Hamza A. Abudayyeh +3 more
doaj +1 more source