Results 51 to 60 of about 18,450 (294)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Canonical contact structures on some singularity links
, 2014 We identify the canonical contact structure on the link of a simple elliptic or cusp singularity by drawing a Legendrian handlebody diagram of one of its Stein fillings.
Akbulut +25 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Self-similar cuspidal formation by runaway thermocapillary forces in thin liquid films
New Journal of Physics, 2019 Many physical systems give rise to dynamical behavior leading to cuspidal shapes which represent a singularity of the governing equation. The cusp tip often exhibits self-similarity as well, indicative of scaling symmetry invariant in time up to a change
Chengzhe Zhou, Sandra M Troian
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Condensed Matter PhysicsWe analyze the equilibrium states of quantum lattice model with local multi-well potentials for Sn2P2S6 ferroelectric crystals using the mean and Gaussian curvatures (H, K), curvedness (C) and shape index (S).
S. Özüm +3 more
doaj +1 more source
Semilinear waves with cusp singularities [PDF]
Journées équations aux dérivées partielles, 1987 Let P be a second order strictly hyperbolic operator with \(C^{\infty}\) coefficients in some open domain \(\Omega \subset {\mathbb{R}}^{1+n}\). The propagation of conormal regularity for bounded solutions of the (weakly) semilinear hyperbolic equation \[ (*)\quad Pu(z)=g(z,u),\quad z\in \Omega,\quad u\in L^{\infty}_{loc}(\Omega),\quad g\in C^{\infty}(\
openaire +2 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
HCMU metrics with cusp singularities and conical singularities
, 2013 An HCMU metric is a conformal metric which has a finite number of singularities on a compact Riemann surface and satisfies the equation of the extremal Kähler metric. In this paper, we give a necessary and sufficient condition for the existence of a kind of HCMU metrics which has both cusp singularities and conical singularities.
Qing, Chen, Yingyi, Wu, Bin, Xu
openaire +2 more sources