Results 201 to 210 of about 1,258,966 (356)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

3D accurate osteotomy for pediatric cubitus varus deformity using a custom-matched surgical osteotomy template combined with a reduction template via a limited lateral incision: a case report and literature review. [PDF]

Front Surg
Guo JL, Zeng X, Guan JH, Chen HY, Zhao K, Zhang MR.   +5 more
europepmc   +1 more source

Custom-Made Ceria Nanoparticles Show a Neuroprotective Effect by Modulating Phenotypic Polarization of the Microglia.

Angewandte Chemie, 2018
Feng Zeng, Ying-Wei Wu, Xinwei Li, Xiaojia Ge, Qinghua Guo, Xiaobing Lou, Zhonglian Cao, Bingwen Hu, N. Long, Ying Mao, Cong Li   +10 more
semanticscholar   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Enhancing Precision in Pelvic Tumor Reconstruction: Early Experience and Iterative Design of Custom 3D-Printed Implants. [PDF]

J Am Acad Orthop Surg Glob Res Rev
Lesensky J, Benes M, Cejka Z, Belzarena AC.   +3 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Custom-made acetabular implants for severe acetabular bone defects: implant evolution, mid-term clinical and radiographic outcomes, and complications in 154 consecutive patients over 18 years. [PDF]

Arthroplasty
Babasiz M, Zellner AA, Babasiz T, Ossendorff R, Fröschen FS, Strauss AC, Jaenisch M, Wirtz DC.   +7 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Pilot evaluation of 3D-designed custom-made integrated mask and headgear for children using non-invasive ventilation. [PDF]

BMJ Open Respir Res
Broadbent M, Shortland S, Willox M, Metherall P, Branchflower J, Craven VE, Elphick HE.   +6 more
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source