Results 281 to 290 of about 1,258,966 (356)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Dimensional accuracy of dental impression materials evaluated using a standardized CAD based method across materials tray types and techniques. [PDF]

Sci Rep
Wassermann C, Rosenberger N, Gerhardt M, Schrenker J, Schmitter M, Hoehne C.   +5 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Custom-Made Mouthpiece-Assisted Oral Cryotherapy During Hematopoietic Stem Cell Transplantation in a Patient With Hemimaxillectomy-Related Oroantral Communication: A Case Report. [PDF]

Clin Case Rep
Matsuzaki K, Miyazaki F, Motoyama Y, Takeda S, Kuboki T, Soga Y.   +5 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

ProbeST: a custom probe design pipeline for dual host-pathogen Spatial Transcriptomics. [PDF]

BMC Genomics
Rouot S, van Dolderen I, Andreassen PR, Frapard S, Herrera-Foessel SA, Sounart H, Saarenpää S, Vorholt JA, Giacomello S.   +8 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Custom distal humerus reconstruction for severe bone loss in revision and complex primary total elbow arthroplasty. [PDF]

JSES Rev Rep Tech
Hysong AA, Oles AR, Tanenbaum JE, Williams JL, Nieboer MJ, Sanchez-Sotelo J, Morrey ME.   +6 more
europepmc   +1 more source

Practical Integration of Open-Source Control Architectures on Custom Quadruped Robots: Simulation Validation and Hardware Interfacing. [PDF]

Sensors (Basel)
Kurumbaparambil V, Rajanayagam S, Twieg S.   +2 more
europepmc   +1 more source

Training the public health workforce for generative AI: validation of the Italian Chatbot Usability Questionnaire. [PDF]

Front Public Health
Baglivo F, Gorga A, Vella G, Barbati C, D'Atri AL, Pecchioli M, De Angelis L, Siliquini R, Mazzucco W, Odone A, Rizzo C.   +10 more
europepmc   +1 more source