Results 91 to 100 of about 289,961 (295)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A survey of the UK tax system [PDF]
, 2006 This document provides an overview of the UK tax system, describing how each of the main taxes works and setting their current state into the context of the past 27 ...
Adam, S., Browne, J.
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Towards a Eurasian economic Union: the challenge of integration and unity [PDF]
, 2012 otherwise – without the prior permission of ...
Blockmans, Steven +2 more
core +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
On a Question of Providing Customs Payment by the Bank Guarantee
Управленческое консультирование, 2018 In the article the legal nature of the bank guarantee, legal status of subjects of the legal relationship arising in connection with its delivery, features of application of the bank guarantee as one of ways of ensuring payment of the customs duties ...
Mikhail Alekseevich Laboskin
doaj
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Import procedures for timber to the European Union : options for streamlining procedures for legal timber [PDF]
, 2008 This report provides a description of the institutions involved in timber import and an overview of import procedures and related documents in the Netherlands in the framework of the European Union Action Plan for Forest Law Enforcement, Governance and ...
Kamphuis, B.M., Verwaart, D.
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
DISADVANTAGES OF THE SYSTEM OF TAXATION OF SUBSOIL USE AND WAYS TO IMPROVE IT
Вестник университета, 2016 The article discusses the main taxes payable by subsoil users today. This export customs duties on oil and gas and the tax on mineral extraction. The main drawback of the tax on extraction of minerals is a flat scale of its use that are subject to the ...
S. Mamaev
doaj