Results 111 to 120 of about 531,594 (274)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Comparative Review of Halal Certification Frameworks for Poultry Meat in Malaysia, Singapore, and Indonesia. [PDF]

Foods
Zhang BZ, Moon JW, Park JM.
europepmc   +1 more source

The Conceptions of Customs Duty and the Customs System as an Insrument of Protectionism

Business Inform
The article discusses the main conceptions of customs duty and the customs system as instruments of economic protectionism, which play a key role in shaping and implementing the foreign economic policy of the State. The author examines the historical development of customs instruments, their classification, and application in various countries ...
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Strengthening supply chains for pathogen genomic surveillance in Asia. [PDF]

BMJ Glob Health
Stona AC, Khoo YK, Moe, Wulandari S, Agoramurthy S, Getchell M, Mak TM, Pang J, Liu EJ, Selva Kumar S, Lim JC, Smith GJD, Bertholet A, Garg A, Harsono S, Magner M, Qadri F, Shirin T, Andalucia LR, Munira SL, Xangsayarath P, Robinson MT, Setk S, Myat Tu H, Arunkumar G, Jha R, Amir A, Ikram A, Nisar I, Dizon T, Saloma C, Malavige NG, De Alwis R, Pronyk PM.   +33 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Customs fraud detection using a gradient boosting approach for joint classification and risk estimation. [PDF]

Sci Rep
Alwanin R, Ismail MMB, Bchir O.
europepmc   +1 more source

The Carrier’s Duty of Customs Summary Declaration

Faṣlnāmah-i Pizhūhish-i Huqūq-i ̒Umūmī, 2020
The goods shall be subject to customs formalities while crossing national borders in international transportation. The main duty to meet the above formalities lies against the cargo owner which, in deed, is assignable to an agent _ who might be the carrier. However, the carrier itself is obliged to submit a summary declaration of the total cargo before
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Imported Cases of Monkeypox Virus Clade Ⅰa - China, 2025. [PDF]

China CDC Wkly
Liu D, Lu Y, Hu C, Yu S, Xue L, Zhang G, Yi Z, Mao M, Li S, Wang Q, Zhang Z, Tian Z.   +11 more
europepmc   +1 more source