Results 61 to 70 of about 515,687 (293)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

LEGISLATIVE FORMATION OF THE BASES OF HARM INDEMNIFICATION IILEGALLY IMPOSED BY THE STATE DURING CRIMINAL PROSECUTION IN THE RUSSIAN EMPIRE PERIOD

Russian Journal of Economics and Law, 2013
The article is devoted to the historical aspect of formation and development of the norms of harm indemnification imposed by unlawful criminal prosecution by the Russian law of 19th – beginning of 20th c.
B. A. Polyakov
doaj  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Perceived Effects of Croatian Customs Services Reform: the Opinion of Forwarders from Istarska County [PDF]

The reforms of the public sector rank among the most complex problems Croatia has to face in the process of transition and accession to the EU. One of the recent reforms, the Customs Service Reform, offers insights into some of the achieved improvements ...
Alen Benazic, Marija Kastelan-Mrak
core  

Митні формальності щодо автомобільних транспортних засобів [PDF]

, 2018
Герман О. О. Митні формальності щодо автомобільних транспортних засобів : автореф. дис. ... канд. юрид. наук : 12.00.07 / Олександр Олександрович Герман ; Нац. ун-т "Одес. юрид. акад". - Одеса, 2018.
Herman, Oleksandr O., Герман, Александр Александрович, Герман, Олександр Олександрович   +2 more
core  

The Tax Avoidance Industry: Accountancy Firms on the Make [PDF]

, 2013
The focus of the paper is upon the financial sector and, more specifically the involvement of global accountancy firms in devising and selling tax avoidance schemes euphemistically marketed as `tax planning?. Commenting upon some of the ?entrepreneurial?
Sikka, P, Willmott, H
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Ukraine’s unimplemented anti-corruption reform. [PDF]

, 2017
Almost three years after the Euromaidan revolution, Ukraine’s leadership has fallen woefully short in delivering on its promises to fight against corruption within the judiciary, clean up political party financing and decentralise government functions ...
Kostanyan, Hrant
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Methodical and methodological principles of research into soil-forming processes in the reference"s and destructive edafotops

RUDN Journal of Ecology and Life Safety, 2014
The article defines the features and principles of researches of soilforming processes in the reference’s and destructive edaphotopes. It is concluded that particularly significant and important ecological role of soil-forming processes in the steppe of ...
E V Gorodyuk
doaj