Results 81 to 90 of about 658,878 (281)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Cut free sequent calculus for logic S5n(ED)

open access: yesLietuvos Matematikos Rinkinys, 2010
Hilbert style, Gentzen style sequent and Kanger style sequent calculi for logic S5n(ED) are considered in this paper. Gentzen style sequent calculus is constructed and its equivalence with Hilbert style system is proved, getting soundness and ...
Haroldas Giedra
doaj   +1 more source

A simple proof that super consistency implies cut elimination [PDF]

open access: yes, 2011
International audienceWe give a simple and direct proof that super-consistency implies the cut elimination property in deduction modulo. This proof can be seen as a simpli cation of the proof that super-consistency implies proof normalization.
Dowek, Gilles   +3 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Multiplicative-Additive Proof Equivalence is Logspace-complete, via Binary Decision Trees [PDF]

open access: yesLogical Methods in Computer Science, 2017
Given a logic presented in a sequent calculus, a natural question is that of equivalence of proofs: to determine whether two given proofs are equated by any denotational semantics, ie any categorical interpretation of the logic compatible with its cut ...
Marc Bagnol
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Modified Anderson-Darling Test-Based Target Detector in Non-Homogenous Environments

open access: yesSensors, 2014
A constant false alarm rate (CFAR) target detector in non-homogenous backgrounds is proposed. Based on K-sample Anderson-Darling (AD) tests, the method re-arranges the reference cells by merging homogenous sub-blocks surrounding the cell under test (CUT)
Yang Li   +3 more
doaj   +1 more source

On Constructive Connectives and Systems [PDF]

open access: yesLogical Methods in Computer Science, 2010
Canonical inference rules and canonical systems are defined in the framework of non-strict single-conclusion sequent systems, in which the succeedents of sequents can be empty.
Arnon Avron, Ori Lahav
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

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