Results 181 to 190 of about 1,075,351 (264)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Predictive factors for poor mobilization in autologous stem cell transplant: a multivariate model. [PDF]

Hematol Transfus Cell Ther
Bagherian M, Jalili M, Mohammadi S, Kamranzadeh H, Mousavi SA, Shamshiri A, Vaezi M, Ferdowsi S.   +7 more
europepmc   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Premeiotic chromatin states orchestrate gene expression during male gametogenesis in rice. [PDF]

Genome Biol
Zhu B, Zhao F, Liu Q, Pu C, Ye M, Bai P, Guiderdoni E, Zhao Y, Zhou DX.   +8 more
europepmc   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Development of a Clinical Severity Score for Indian Sickle Cell Anaemia Patients. [PDF]

EJHaem
Nongmaithem SS, Biswas A, Iyer S, Vyshnavi J, Wath A, Chandak GR, Jain D.   +6 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Single B-Cell-Based Generation of Porcine Anti-CSFV E^rns Monoclonal Antibodies and Application in a Blocking ELISA Assay. [PDF]

Int J Mol Sci
Huang Y, Li J, Li F, Zhao J, Xu L, Zou X, Li Q, Zhu J, Li Y, Xia Y, Liu Y, Zhao Q, Zhu Y.   +12 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Predictive factors of c-TESE success in eastern algerian patients with non-obstructive azoospermia: role of histology, hormones, and testicular volume. [PDF]

Basic Clin Androl
Nourine BHA, Ounis L, Hamoul M, Haddad FZ, Zoghmar A.   +4 more
europepmc   +1 more source