Results 211 to 220 of about 1,075,351 (264)

MBD3 deficiency decommissions the nucleosome remodeling and deacetylase complex and orchestrates the epigenetic regulation of gene expression to suppress neuroblastoma progression. [PDF]

Neuro Oncol
Chen C, Guo B, Wu S, Zhu Q, Shi H, Wang J, Shu Q, Tao T.   +7 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A Systematic Review and Meta-Analysis of the Impact of Tumour Mutation Burden on Survival Outcomes in Solid Tumours. [PDF]

Cancer Med
Meng A, Yuile A, Sim HW, Thavaneswaran S, Noor H, Yeung J, Mehta A, Powell J, Zaman A.   +8 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Development of a flow cytometry method to measure antidrug antibodies against CAR T cells. [PDF]

Immunohorizons
Day G, Sánchez-Martín FJ, Seavers L, Cadwallader K, Morgado-García S.   +4 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Identification of tumor-promoting functions of the Homeobox family transcription factor MSX1 in cervical cancer. [PDF]

Cell Death Discov
Brücker P, Horn S, Jansari S, Kombou M, Eppich S, Jeschke U, Hakroush S, Küffer S, Fritzsche S, Wegwitz F, Gallwas J.   +10 more
europepmc   +1 more source

KAT6A is essential for developmental control gene expression in neural stem and progenitor cells. [PDF]

PLoS Genet
Voss AK, Eccles S, Wichmann J, Abeysekera W, Bergamasco MI, Garnham AL, Ranathunga N, Yang Y, Bowden R, Smyth GK, Thomas T.   +10 more
europepmc   +1 more source