Results 81 to 90 of about 118,600 (325)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

A simple proof that super consistency implies cut elimination [PDF]

open access: yes, 2011
International audienceWe give a simple and direct proof that super-consistency implies the cut elimination property in deduction modulo. This proof can be seen as a simpli cation of the proof that super-consistency implies proof normalization.
Dowek, Gilles   +3 more
core   +1 more source

On the Herbrand content of LK [PDF]

open access: yesElectronic Proceedings in Theoretical Computer Science, 2016
We present a structural representation of the Herbrand content of LK-proofs with cuts of complexity prenex Sigma-2/Pi-2. The representation takes the form of a typed non-deterministic tree grammar of order 2 which generates a finite language of first ...
Bahareh Afshari   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A Simple Proof That Super-Consistency Implies Cut Elimination [PDF]

open access: yes, 2023
We give a simple and direct proof that super-consistency implies the cut elimination property in deduction modulo. This proof can be seen as a simplification of the proof that super-consistency implies proof normalization.
Dowek, Gilles, Hermant, Olivier
core   +1 more source

The Financial Impact of Eliminating a NCAA Division I Men’s Sport on the Athletic Budget: Is Title IX to Blame?

open access: yesJournal of Intercollegiate Sport, 2023
The purpose of this study was to examine changes to the budgets of women’s athletics, men’s basketball, and football when an NCAA Division I intercollegiate men’s team was eliminated.  Stakeholder theory provided the theoretical framework for the study. 
Anne Marx, Joel Cormier, Roman Ciapalo
doaj  

Modified Anderson-Darling Test-Based Target Detector in Non-Homogenous Environments

open access: yesSensors, 2014
A constant false alarm rate (CFAR) target detector in non-homogenous backgrounds is proposed. Based on K-sample Anderson-Darling (AD) tests, the method re-arranges the reference cells by merging homogenous sub-blocks surrounding the cell under test (CUT)
Yang Li   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Algebraic proofs of cut elimination [PDF]

open access: yes, 2008
Algebraic proofs of the cut-elimination theorems for classical and intuitionistic logic are presented, and are used to show how one can sometimes extract a constructive proof and an algorithm from a proof that is nonconstructive.
Jeremy Avigad
core  

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