Results 171 to 180 of about 130,249 (264)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Moderate Light Intensity Optimizes Forage Nutritive Value While Maintaining Morphophysiological Stability and Secondary Metabolite Concentrations in <i>Plantago lanceolata</i> L. Under Controlled Environmental Conditions. [PDF]

Plants (Basel)
Merino VM, Piña LF, Rivero MJ, Stolpe NB, Bascuñán LL, Castro PA, Ortiz JM, López MD, Gómez GE, Concha BR.   +9 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Isolation, Identification, and Diversity Analysis of Endophytic Fungi from Sweetpotato. [PDF]

J Fungi (Basel)
Wang SX, Li J, Zhang XX, Xu HH, Huang LF.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Tracing Selenium Uptake in Wheat Leaves via Liposome-Mediated Delivery: A Confocal Microscopy and Synchrotron Micro-X-ray Fluorescence Insight. [PDF]

ACS Agric Sci Technol
Viltres-Portales M, Sánchez-Martín MJ, Boada R, Llugany M, Valiente M.   +4 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

A robust technique for gas-exchange measurements using petiole-cut Arabidopsis leaves in a whole plant chamber. [PDF]

Plant Cell Physiol
Kinoshita SN, Finkemeier I.
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

A strong, reversible, and conformal adhesive gel for diverse plants. [PDF]

Sci Adv
Zhao J, Guan Z, Luthra R, Opdensteinen P, Ho B, Li X, Park YJ, Kwak MS, Ko H, Steinmetz NF, Bae J.   +10 more
europepmc   +1 more source