Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Isolation and Transfection of Protoplasts From Maize Mesophyll Cells. [PDF]
Higa LA, Bouwman T, Du ZY.
europepmc +1 more source
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Leaf Ontogeny Shapes Divergent Physiological and Metabolic Responses to Contrasting Nitrogen Forms in Chinese Fir (<i>Cunninghamia lanceolata</i> (Lamb.) Hook). [PDF]
Fu WY +6 more
europepmc +1 more source
Axial Tracheids Widening Across Vein Orders in <i>Ginkgo biloba</i> Leaves and Their Relationship with Hydraulic Path Length. [PDF]
Qunzong G, Cao Y, Guo Q, Zhong M.
europepmc +1 more source
Excision increases branch water potential but generally reduces leaf gas exchange. [PDF]
Cross M, Michaletz ST.
europepmc +1 more source
Impact of Insect Prey and Plant Food Sources on Development and Reproduction of the Phytozoophagous Mirid Bug, <i>Apolygus lucorum</i> (Meyer-Dür). [PDF]
Wang L, Li L, Liu B, Wu K.
europepmc +1 more source
Morphological, yield, and nutritional characteristics of Chicory (<i>Cichorium intybus</i> L.) and Plantain (<i>Plantago lanceolata</i> L.) according to cutting interval in Peruvian Andes. [PDF]
Paucar Y +11 more
europepmc +1 more source

