Results 121 to 130 of about 567,722 (314)

Extraocular well-differentiated sebaceous tumors with overlying cutaneous horns: four tumors in three patients

, 2017
BackgroundSebaceous tumors are adnexal neoplasms showing sebocytic differentiation. They range from benign to malignant and are associated with Muir-Torre syndrome (MTS).
郭冠廷;蔡佳惠;廖述朗;廖肇裕, Jhuang, Jie-Yang;Liao, Shu-Lang;Tsai, Jia-Huei;Chang, Hsiao-Ching;Kuo, Kuan-Ting;Liau, Jau-Yu   +1 more
core   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Cutaneous drug reactions

, 2017
The thesis looks at adverse reactions of drugs on the skin. The mechanism by which drugs cause adverse reactions is described. The morphology of cutaneous reactions is also described.
Chikomba, Leonell
core  

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

Urticaria as a cutaneous sign of adult-onset Still's disease

, 2006
Background. the cardinal signs and symptoms of adult-onset Still's disease (AOSD) include periodic fever, arthralgia and arthritis, lymphadenopathy, hepatosplenomegaly, an evanescent rash accompanied by neutrophilic granulocytosis, and a negative ...
Costa Martins, Jose Eduardo, Criado, Paulo Ricardo, Vasconcellos, Cidia, Criado, Roberta F. J., Szajubok, Jose Carlos M., Michalany, Nilceo S., Kadunc, Bogdana Victoria   +6 more
core   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Pleomorphic dermal sarcoma of the scalp: Review of management and distinguishing features from atypical fibroxanthoma

JAAD Case Reports, 2022
Alexa J. Cohen, BS, Sahithi Talasila, BS, Bojan Lazarevic, BA, Laura Gleason, BS, Viral Patel, MD, Neda Nikbakht, MD, PhD   +5 more
doaj   +1 more source

Human cutaneous sensitivity eBook

, 2013
This resource was designed for use by second year undergraduate neuroscience students, taking the University of Leeds module BMSC2227: experimental skills in neuroscience.
Jonah Ciccone, Dr Anne King, Dr Neil Morris   +2 more
core  

Perforating cutaneous metastasis from an ovarian adenocarcinoma

, 2010
Cutaneous metastasis from ovarian cancer usually presents clinically as firm papules and nodules on the trunk. Histology commonly exhibits a dermal infiltrate of malignant cells.
Salem Z., Haddad F., Abbas O., Kibbi A.-G.   +3 more
core   +1 more source

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source