Results 171 to 180 of about 1,185,716 (346)

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu   +6 more
wiley   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

open access: yesAdvanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen   +8 more
wiley   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

open access: yesAdvanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen   +11 more
wiley   +1 more source

Recurrent halo nevus: Dermoscopy and confocal microscopy features

open access: yesJAAD Case Reports, 2017
Ana Carolina Porto, MD   +7 more
doaj   +1 more source

323 IL-22 promotes early aggressive behavior of cutaneous squamous cell carcinoma (SCC); A murine xenograft model [PDF]

open access: bronze, 2017
Melody Abikhair   +5 more
openalex   +1 more source

Genomic Classification of Cutaneous Melanoma

open access: yesCell, 2015
Rehan Akbani   +351 more
semanticscholar   +1 more source

Contemporary outbreaks of different avipoxviruses in Humboldt penguins of wild animal park Planckendael and in chickens of commercial poultry farms in Belgium [PDF]

open access: yes, 2017
In the present study, the first outbreak of a penguinpox virus (PPV) in Humboldt penguins (Spheniscus humboldd) and four outbreaks of fowlpox virus (FPV) in layer chickens are reported.
Avalakuppa Papi Reddy, Vishwanatha Reddy   +3 more
core  

Early Radial Extracorporeal Shockwave Stimulation on Proximal Tibial Circular Osteotomy Site Enhanced Heterotopic Skin Wound Healing via Small Extracellular Vesicles

open access: yesAdvanced Science, EarlyView.
A schematic diagram of the mechanism where small extracellular vesicles mediate the enhancement of heterotopic wound healing by radial extracorporeal shockwave stimulation at a proximal tibial osteotomy site. ABSTRACT Wound healing represents a complex biological process necessitating innovative therapeutic approaches, particularly for chronic wounds ...
Xiaoping Xie   +8 more
wiley   +1 more source

Melanocytic nevi and melanoma: overlapping criteria—the degree is the key

open access: yesDermatology Practical & Conceptual, 2014
Robert M. Hurwitz   +2 more
doaj   +1 more source

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