Results 41 to 50 of about 748,340 (348)

Exosome-Derived microRNA: Potential Target for Diagnosis and Treatment of Sepsis

open access: yesJournal of Immunology Research
Exosome-derived microRNAs (miRNAs) are emerging as pivotal players in the pathophysiology of sepsis, representing a new frontier in both the diagnosis and treatment of this complex condition.
Yujie Xiao   +3 more
doaj   +1 more source

Cutaneous Sialidase

open access: yesJournal of Investigative Dermatology, 1982
A fluorometric microassay is described for sialidase using the natural substrate sialyllactose. This technique has been used to characterize and quantify cutaneous sialidase. The enzyme was found exclusively in the particulate fraction of skin homogenates.
Mier, P.D.   +3 more
openaire   +2 more sources

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Exosomes derived from mouse vibrissa dermal papilla cells promote hair follicle regeneration during wound healing by activating Wnt/β-catenin signaling pathway

open access: yesJournal of Nanobiotechnology
Hair follicle (HF) regeneration during wound healing continues to present a significant clinical challenge. Dermal papilla cell-derived exosomes (DPC-Exos) hold immense potential for inducing HF neogenesis.
Yage Shang   +15 more
doaj   +1 more source

In Situ Transformation of Electrospun Nanofibers into Nanofiber-Reinforced Hydrogels

open access: yesNanomaterials, 2022
Nanofiber-reinforced hydrogels have recently gained attention in biomedical engineering. Such three-dimensional scaffolds show the mechanical strength and toughness of fibers while benefiting from the cooling and absorbing properties of hydrogels as well
Alma Martin   +8 more
doaj   +1 more source

Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology

open access: yesFrontiers in Oncology, 2019
Papillomaviridae is a family of small non-enveloped icosahedral viruses with double-stranded circular DNA. More than 200 different human papillomaviruses (HPVs) have been listed so far.
T. Gheit
semanticscholar   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Exosomes as novel biomarkers in sepsis and sepsis related organ failure

open access: yesJournal of Translational Medicine
Sepsis, a severe and life-threatening condition arising from a dysfunctional host response to infection, presents considerable challenges to the health care system and is characterized by high mortality rates and substantial economic costs. Exosomes have
Yixuan Yuan   +13 more
doaj   +1 more source

Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts

open access: yesScientific Reports, 2016
Prolonged healing and scar formation are two major challenges in the treatment of soft tissue trauma. Adipose mesenchymal stem cells (ASCs) play an important role in tissue regeneration, and recent studies have suggested that exosomes secreted by stem ...
Li-juan Hu   +8 more
semanticscholar   +1 more source

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