Results 41 to 50 of about 567,722 (314)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Mitochondrial transfer via ADSC-EVs reprograms glucose/glutamine metabolism to restore TCA cycle-driven M2 polarization in diabetic wounds

Journal of Nanobiotechnology
Chronic diabetic wounds are trapped in a persistent inflammatory state, largely due to macrophage failure to transition from pro-inflammatory (M1) to pro-reparative (M2) phenotypes.
Yue Zhang, Fei Han, Yixuan Yuan, Mengyang Li, Linbin Yi, Yujie Xiao, Dongliang Zhang, Zhi Zhang, Yunchuan Wang, Hongtao Wang, Dahai Hu   +10 more
doaj   +1 more source

Efficacy and safety of topical treatments for seborrheic keratoses: a systematic review

Journal of Dermatological Treatment, 2023
Seborrheic keratoses (SKs) are benign epidermal neoplasms presenting as waxy, brown to black papules and plaques. Patients often seek removal for cosmetic reasons or irritation. The objective of this systematic review is to assess the efficacy and safety
Nicole Natarelli, Amanda Krenitsky, Kerry Hennessy, Sarah Moore, James Grichnik   +4 more
doaj   +1 more source

A Practical Approach to the Diagnosis of Lymphedema: a Narrative Review

Dermatology Practical & Conceptual, 2023
Introduction: Lymphedema often presents as progressive, unremitting swelling and skin changes that are extremely distressing to patients. Hereditary lymphedema (HL) constitutes a type of primary lymphedema that is passed down through generations ...
Lauren Banner, Alexa Cohen, Viral Patel, Neda Nikbakht   +3 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Exosomes derived from mouse vibrissa dermal papilla cells promote hair follicle regeneration during wound healing by activating Wnt/β-catenin signaling pathway

Journal of Nanobiotechnology
Hair follicle (HF) regeneration during wound healing continues to present a significant clinical challenge. Dermal papilla cell-derived exosomes (DPC-Exos) hold immense potential for inducing HF neogenesis.
Yage Shang, Mengyang Li, Lixia Zhang, Chao Han, Kuo Shen, Kejia Wang, Yan Li, Yue Zhang, Liang Luo, Yanhui Jia, Kai Guo, Weixia Cai, Jian Zhang, Xujie Wang, Hongtao Wang, Dahai Hu   +15 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

First-line ipilimumab plus nivolumab in advanced merkel cell carcinoma: a meta-analysis of prospective trials and real-world validation cohort

Cancer Immunology, Immunotherapy
Background Advanced Merkel cell carcinoma (MCC) has a high response rate to immune checkpoint blockade (ICB). While early phase studies have demonstrated activity of dual ICB with anti-PD-1 plus anti-CTLA-4 agents in both the first- and second-line ...
Tanya Ramadoss, Christian Palacios, Matthew Nichols, Zeynep Eroglu, Joseph Markowitz, Lilit Karapetyan, Ahmad A. Tarhini, Evan J. Wuthrick, Vernon K. Sondak, Kenneth Y. Tsai, Nikhil I. Khushalani, Andrew S. Brohl   +11 more
doaj   +1 more source

Increased Risk of Postoperative Complications in Patients with Hypertension Undergoing Mohs Micrographic Surgery

JID Innovations
Hypertension has been previously associated with higher intraoperative bleeding risk in patients undergoing Mohs micrographic surgery. However, the risks of common postoperative Mohs micrographic surgery complications have not been substantiated by large
Alexandra Elder, Henry Y. Yang, Megan O’Donnell-Cappelli, Jenna L. Mandel, Molly Wallace, Lauren Banner, Ramsay Hafer, Thomas Z. Rohan, Neda Nikbakht   +8 more
doaj   +1 more source

Treatment of localised cutaneous Leishmania tropica infection in Aleppo, Syria and drug sensitivity of clinical isolates [PDF]

Anthroponotic cutaneous leishmaniasis caused by Leishmania tropica has been endemic in Aleppo, Syria for centuries. The first modem description of the disease was also done in Aleppo.
Abazid, Nizar
core   +1 more source