Results 91 to 100 of about 145,153 (301)

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Vascular function and cardiovascular risk factors in women with severe flushing [PDF]

, 2010
Background: Seventy per cent of postmenopausal women suffer from hot flushes causing significant morbidity in 25%. Oestrogen replacement provides symptom relief, but its use has declined following safety issues and there is, as yet, no good alternative ...
J. Sassarini, H. Fox, M. A. Lumsden, Fox, H., Sassarini, J., Ferrell, W., N. Sattar, Sattar, N., W. Ferrell, Lumsden, M.A.   +9 more
core   +1 more source

Transcutaneous radiofrequency in the treatment of plantar fasciitis-related pain: a case series

Journal of the Foot & Ankle
Introduction: Plantar fasciitis (PF) is a multifactorial painful syndrome. Treatment is generally conservative, but 20% to 30% of cases become refractory, requiring the combination of therapies for pain relief.
Rosimary Amorim Lopes, Alvaro Henrique de Souza Oliveira Filho, Daiany Villar da Silva, Wellington Farias Molina, Ricardo Vieira Botelho, Jose Oswaldo de Oliveira Júnior   +5 more
doaj   +1 more source

Transdermal drug delivery treatment for overactive bladder

International Brazilian Journal of Urology, 2006
Overactive bladder is commonly treated with oral anticholinergic drugs such as oxybutynin chloride. Although oral anticholinergic agents have been effective in controlling urinary urgency and incontinence, adverse events, particularly dry mouth, often ...
Roger R. Dmochowski, Jonathan S. Starkman, G. Willy Davila   +2 more
doaj   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Topical and cutaneous delivery using nanosystems

, 2017
The goal of topical and cutaneous delivery is to deliver therapeutic and other substances to a desired target site in the skin at appropriate doses to achieve a safe and efficacious outcome.
Roberts, M., Namjoshi, S., Leite Silva, V.R., Abd, E., Roberts, M. S., Pastore, M.N., Leite-Silva, V. R. [UNIFESP], Roberts, M.S., Grice, J. E., Mohammed, Y., Yousef, S., Pastore, M. N., Haridass, I. N., Pastore, M., Leite-Silva, V., Grice, J.E., Benson, H. A. E., Benson, H.A.E., Haridass, I., Grice, J., Alinaghi, A., Haridass, I.N., Benson, Heather   +22 more
core   +1 more source

TREATMENT AND OUTCOME OF HORSES WITH CUTANEOUS PYTHIOSIS, AND META-ANALYSIS OF SIMILAR REPORTS

Slovenian Veterinary Research, 2019
Pythiosis is reported to be one of the most life-threatening infections of people and animals in tropical, subtropical and temperate areas worldwide. Infection can result from ingesting zoospores of Pythium insidiosum organism or from contact with water
Hoda Elkhenany, Shady Nabil, Howaida Abu-Ahmed, Hassan Mahmoud, Ahmed Korritum, Hoda Khalifa   +5 more
doaj   +1 more source

Effects of cutaneous administration of an over-the-counter menthol cream during temperate-water immersion for exercise-induced hyperthermia in men. [PDF]

Front Physiol, 2023
Wang G, Hurr C.
europepmc   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Biocompatible polymer–metal–organic framework composite patches for cutaneous administration of cosmetic molecules

, 2016
International audienceDespite increasing interest in metal–organic frameworks (MOFs) in the biomedical field, developing specific formulations suitable for different administration routes is still a main challenge. Here, we propose a simple, fast and bio-
Márquez, Alfonso García, Blanco-Prieto, María Jose, Hidalgo, Tania, Horcajada, Patricia, Lana, Hugo, Álvarez-Lorenzo, Carmen, Sanchez, Clément, Boissière, Cédric, Cunha, Denise, Serre, Christian   +9 more
core   +1 more source