Results 91 to 100 of about 401,321 (268)

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe, Vishal Satikuvar, Tanjia M. Syeda, Monica Cal, Pascal Mäser, Marcel Kaiser, Hachemi Kadri   +6 more
wiley   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1087-1097, April 2026.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Leishmania (Mundinia) orientalis n. sp. (Trypanosomatidae), a parasite from Thailand responsible for localised cutaneous leishmaniasis

Parasites & Vectors, 2018
Leishmaniasis is an emerging disease in Thailand with an unknown incidence or prevalence. Although the number of properly characterized and clinically confirmed cases is about 20, it is suspected that this low number masks a potentially high prevalence ...
N. Jariyapan, Teerada Daroontum, Krit Jaiwong, Wetpisit Chanmol, N. Intakhan, S. Sor-Suwan, P. Siriyasatien, P. Somboon, M. Bates, P. Bates   +9 more
semanticscholar   +1 more source

Evaluation and Comparison of Personality Traits in Patients with Genital Wart and Healthy Individuals

مجله دانشکده پزشکی اصفهان, 2019
Background: Genital wart is a sexually transmitted disease, which can have specific psychological causes and consequences. We aimed to compare personality traits among the patients with genital warts and healthy people. Methods: Seventy participants (35
Arezoo Moradi, Seyyed Kazem Rasoulzadeh-Tabtabaei, Mahdi Razmara, Emadodin Darchini-Maragheh, Maryam Saeidi, Vahid Mashayekhi   +5 more
doaj   +1 more source

Cutaneous Leishmaniasis in Saudi Arabia: A Comprehensive Overview

Vector Borne and Zoonotic Diseases, 2017
Despite the great efforts by health authorities in Kingdom of Saudi Arabia (KSA), Cutaneous leishmaniasis (CL) continues to be a major public health problem in the country.
A. Abuzaid, Abdalmohsin M. Abdoon, Mohamed A. Aldahan, A. Alzahrani, R. F. Alhakeem, Abdullah M. Asiri, M. Alzahrani, Z. Memish   +7 more
semanticscholar   +1 more source

Limited Activity Of Miltefosine In Murine Models Of Cryptococcal Meningoencephalitis And Disseminated Cryptococcosis [PDF]

, 2013
Miltefosine is an alkyl phosphocholine with good oral bioavailability and in vitro activity against Cryptococcus species that has gained interest as an additional agent for cryptococcal infections.
Bocanegra, Rosie, Kirkpatrick, William R., Najvar, Laura K., Patterson, Thomas F., Sorrell, Tania C., Wiederhold, Nathan P.   +5 more
core   +1 more source

Brain Involvement in Leishmaniasis

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Camila S. Freitas, Eduardo A. F. Coelho, Myron Christodoulides   +2 more
wiley   +1 more source

Kidney involvement in leishmaniasis—a review

Brazilian Journal of Infectious Diseases, 2014
Leishmaniasis is an infectious disease caused by protozoa of the genus Leishmania transmitted by insects of the genus Lutzomyia sp. or Phlebotomus sp.
Geraldo Bezerra da Silva Junior, Elvino José Guardão Barros, Elizabeth De Francesco Daher   +2 more
doaj   +1 more source

'We do not rush to the hospital for ordinary wounds (suḷu tuvāla)': A qualitative study on the early clinical manifestations of cutaneous leishmaniasis and associated health behaviours in rural Sri Lanka.

PLoS Neglected Tropical Diseases, 2023
BackgroundKnowledge of early clinical manifestations, people's perceptions and behaviours is crucial in preventing and controlling neglected tropical diseases (NTDs).
Sonali Dinushika Gunasekara, Nuwan Darshana Wickramasinghe, Suneth Buddhika Agampodi, Manoj Sanjeewa Fernando, Kosala Gayan Weerakoon, Chandani Liyanage, Lisa Dikomitis, Thilini Chanchala Agampodi   +7 more
doaj   +1 more source

American Cutaneous Leishmaniasis [PDF]

Journal of the Royal Army Medical Corps, 1983
This review outlines the present knowledge of American cutaneous leishmaniasis, a disease which, owing to the increase in international travel, is being seen with increasing frequency in Europe and North America. A knowledge of this disease is of particular importance to the military medical officer as in recent years approximately one-hundred and ...
openaire   +2 more sources