Results 1 to 10 of about 120,500 (221)
Inhibition of trypsin expression in Lutzomyia longipalpis using RNAi enhances the survival of Leishmania [PDF]
, 2009 Background Leishmania parasites must overcome several barriers to achieve transmission by their sand fly vectors. One of the earliest threats is exposure to enzymes during blood meal digestion.
Rod J Dillon +17 more
core +5 more sources
Antibiotic-Free Nanoplasmids as Promising Alternatives for Conventional DNA Vectors
Vaccines, 2022 DNA vaccines with their extraordinary properties are the best choice as vectors for subunit vaccines but are not in compliance with safety regulations, mainly because of the antibiotic resistance genes on their backbone.
Negar Seyed +6 more
doaj +1 more source
Frontiers in Immunology, 2022 Leishmaniasis is a neglected vector-borne disease caused by Leishmania parasites transmitted through the infected sand flies bite. Current treatments are limited, partly due to their high cost and significant adverse effects, and no human vaccine is yet ...
Mahya Sadat Lajevardi +8 more
doaj +1 more source
T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection : is this paradigm still relevant? [PDF]
, 2012 Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively.
Brombacher, F., Alexander, J.
core +4 more sources
Parasites & Vectors, 2022 Background Leishmania parasites are deposited in the host through sand fly bites along with sand fly saliva. Therefore, salivary proteins are promising vaccine candidates for controlling leishmaniasis.
Mahya Sadat Lajevardi +4 more
doaj +1 more source
Promastigote-to-Amastigote Conversion in Leishmania spp.—A Molecular View
Pathogens, 2022 A key factor in the successful infection of a mammalian host by Leishmania parasites is their conversion from extracellular motile promastigotes into intracellular amastigotes. We discuss the physical and chemical triggers that induce this conversion and
Joachim Clos +2 more
doaj +1 more source
Experimental treatment with sodium stibogluconate of hamsters infected with Leishmania (Leishmania) chagasi and Leishmania (Leishmania) amazonensis [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 1999 The present paper reports the experimental treatment of hamsters infected with Leishmania chagasi and Leishmania amazonensis with sodium stibogluconate (20mg/kg/day x 20 days). Only with L. chagasi did the treatment result in the complete elimination of parasites from the spleen. However, no parasitological cure was achieved in hamsters infected with L.
Figueiredo, Elizabeth M. de +2 more
openaire +4 more sources
Iranian Journal of Parasitology, 2020 Background: Visceral leishmaniasis is the most severe form of leishmaniasis caused by Leishmania (L.) donovani complex. Drug-resistant strains have been developed as a consequence of the current chemotherapeutic interventions, which has increased the ...
Yasaman TASLIMI +6 more
doaj +1 more source
Veterinary Sciences, 2023 The in vitro cultivation of Leishmania and Trypanosoma parasites plays an important role in the diagnosis and treatment of parasitic diseases. Although Evans’s modified Tobie and Novy–MacNeal–Nicolle media, for Leishmania spp.
Germano Castelli +7 more
doaj +1 more source
The role of surface glycoconjugates in Leishmania midgut attachment examined by competitive binding assays and experimental development in sand flies [PDF]
, 2013 SUMMARY Binding of promastigotes to the sand fly midgut epithelium is regarded as an essential part of the Leishmania life cycle in the vector. Among Leishmania surface molecules putatively involved in attachment to the sand fly midgut, two GPI-anchored ...
Jecna, Lucie +6 more
core +5 more sources