Results 11 to 20 of about 172,432 (281)

Structural basis of secreted acid phosphatase polymerization in the Leishmania parasite. [PDF]

Protein Sci
Abstract Enzymes that assemble into filaments typically transition between protomeric and polymeric states in response to cellular conditions. In contrast, the secreted acid phosphatase (SAP) of Leishmania, one of the most abundant extracellular glycoproteins produced by the parasite and regarded as a major virulence factor in the neglected tropical ...
Bose P, Dahan I, Upcher A, Zalk R, Grossman-Haham I.   +4 more
europepmc   +2 more sources

Heterogeneities in leishmania infantum infection : using skin parasite burdens to identify highly infectious dogs [PDF]

, 2013
Background: The relationships between heterogeneities in host infection and infectiousness (transmission to arthropod vectors) can provide important insights for disease management.
A Mohammadiha, A Mohammadiha, ANS Maia-Elkhoury, AP da Costa-Val, AP Galvani, BL Travi, BLA Vercosa, C Carson, C Fraser, C Mary, C Mary, CDL Oliveira, CHN Costa, CHN Costa, Connor Carson, DJ Shaw, DW Dowdy, EM Michalsky, GA Soper, IFGd Amorim, JO Lloyd-Smith, KJ Esch, KTD Eames, L Dipineto, L Manna, L Manna, L Matthews, Leo Calvo-Bado, LHdS Marques, LLH Lau, Lourdes M. Garcez, LVR Lima, M Chase-Topping, Marleen Boelaert, MEJ Woolhouse, O Courtenay, O Courtenay, O Courtenay, O Francino, Orin Courtenay, PF Quaresma, R Lainson, R Molina, R Molina, R Verin, RA Stein, RB Gomes, RC Giunchetti, RJ Quinnell, RJ Quinnell, RJ Quinnell, RJ Quinnell, RM Anderson, RM May, Rupert J. Quinnell, S Bossolasco, SdA Ferreira   +56 more
core   +7 more sources

Genome-wide mapping reveals single-origin chromosome replication in Leishmania, a eukaryotic microbe [PDF]

, 2015
Background DNA replication initiates on defined genome sites, termed origins. Origin usage appears to follow common rules in the eukaryotic organisms examined to date: all chromosomes are replicated from multiple origins, which display variations in ...
Campbell, Samantha J., Dickens, Nicholas J., Marques, Catarina A., McCulloch, Richard, Paape, Daniel   +4 more
core   +2 more sources

Intra- and interspecific polymorphisms ofLeishmania donovani andL. tropica minicircle DNA [PDF]

, 1994
A pair of degenerate polymerase chain reaction (PCR) primers (LEI-1, TCG GAT CC[C,T] [G,C]TG GGT AGG GGC GT; LEI-2, ACG GAT CC[G,C] [G,C][A,C]C TAT [A,T]TT ACA CC) defining a 0.15-kb segment ofLeishmania minicircle DNA was constructed.
AJ Magill, DC Barker, DF Smith, DG Higgins, F Sanger, GZ Kidane, H. Rinder, JM Blackwell, K Stuart, MHL Bruijn de, P. Dobner, R Sommer, RD Kreutzer, S Lee, T Laskay, T. L�scher, WO Rogers   +16 more
core   +1 more source

Native rodent species are unlikely sources of infection for Leishmania (Viannia) braziliensis along the Transoceanic Highway in Madre de Dios, Peru. [PDF]

, 2014
An estimated 2.3 million disability-adjusted life years are lost globally from leishmaniasis. In Peru's Amazon region, the department of Madre de Dios (MDD) rises above the rest of the country in terms of the annual incidence rates of human leishmaniasis.
Conrad, Patricia A, De Los Santos, Maxy, Ghersi, Bruno M, Lescano, Andres G, Mazet, Jonna AK, Montgomery, Joel M, Razuri, Hugo, Shender, Lisa A   +7 more
core   +9 more sources

Seroepidemiology and molecular diversity of Leishmania donovani complex in Georgia [PDF]

, 2016
Background Leishmaniasis includes multiple clinical syndromes, most notably visceral, cutaneous, and mucosal forms. Visceral leishmaniasis (VL), also known as kala-azar, is a potentially fatal disease endemic to large parts of Africa and Asia, and in ...
Adeishvili, Ekaterine, Babuadze, Giorgi, Carrillo, Eugenia, Chakhunashvili, Giorgi, Chanturia, Gvantsa, De Koning, Harry P., Farlow, Jason, Imnadze, Paata, Kalandadze, Irine, Karseladze, Irakli, Kekelidze, Merab, Kokaia, Nora, Markhvashvili, Ivane, Murskvaladze, Mari, Sidamonidze, Ketevan, Tsereteli, David   +15 more
core   +3 more sources

Upscaling the surveillance of tick-borne pathogens in the French Caribbean Islands [PDF]

, 2020
Despite the high burden of vector-borne disease in (sub)tropical areas, few information are available regarding the diversity of tick and tick-borne pathogens circulating in the Caribbean.
Albina, Emmanuel, Aprelon, Rosalie, Delannoy, Sabine, Devillers, Elodie, Galon, Clémence, Gondard, Mathilde, Moutailler, Sara, Pinarello, Valérie, Pradel, Jennifer, Vayssier-Taussat, Muriel   +9 more
core   +3 more sources

Inhibitory effect of O-propargyllawsone in A549 lung adenocarcinoma cells

BMC Complementary Medicine and Therapies, 2023
Background Lung cancer is the deadliest type of cancer in the world and the search for compounds that can treat this disease is highly important. Lawsone (2-hydroxy-1,4-naphtoquinone) is a naphthoquinone found in plants from the Lawsone genus that show a
Edmilson Willian Propheta dos Santos, Rauan Cruz de Sousa, Mariana Nobre Farias de Franca, Jileno Ferreira Santos, Flaviano Melo Ottoni, Raquel Geralda Isidório, Waldecy de Lucca Junior, Ricardo José Alves, Ricardo Scher, Cristiane Bani Corrêa   +9 more
doaj   +1 more source

Experimental treatment with sodium stibogluconate of hamsters infected with Leishmania (Leishmania) chagasi and Leishmania (Leishmania) amazonensis [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 1999
The present paper reports the experimental treatment of hamsters infected with Leishmania chagasi and Leishmania amazonensis with sodium stibogluconate (20mg/kg/day x 20 days). Only with L. chagasi did the treatment result in the complete elimination of parasites from the spleen. However, no parasitological cure was achieved in hamsters infected with L.
Figueiredo, Elizabeth M. de, Silva, Jaime Costa e, Brazil, Reginaldo P.   +2 more
openaire   +4 more sources

Anti-proliferative and pro-apoptotic activity of glycosidic derivatives of lawsone in melanoma cancer cell

BMC Cancer, 2021
Background Melanoma is a malignant cancer that affects melanocytes and is considered the most aggressive skin-type cancer. The prevalence for melanoma cancer for the last five year is about one million cases.
Mariana Nobre Farias de Franca, Raquel Geralda Isidório, João Henrique Oliveira Bonifacio, Edmilson Willian Propheta dos Santos, Jileno Ferreira Santos, Flaviano Melo Ottoni, Waldecy de Lucca Junior, Ricardo Scher, Ricardo José Alves, Cristiane Bani Corrêa   +9 more
doaj   +1 more source