Results 41 to 50 of about 53,720 (250)

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Clinical and epidemiological aspects of American cutaneous leishmaniasis with genital involvement, [PDF]

Anais Brasileiros de Dermatologia, 2020
Genital lesions are an unusual presentation of American cutaneous leishmaniasis. Conditions such as disseminated cutaneous leishmaniasis and HIV infection may be associated with genital involvement.
Marcelo Rosandiski Lyra, Alan Bittencourt da Silva, Cláudia Maria Valete-Rosalino, Maria Inês Fernandes Pimentel   +3 more
doaj   +1 more source

Gene expression in Leishmania is regulated predominantly by gene dosage [PDF]

, 2017
Leishmania tropica, a unicellular eukaryotic parasite present in North and East Africa, the Middle East, and the Indian subcontinent, has been linked to large outbreaks of cutaneous leishmaniasis in displaced populations in Iraq, Jordan, and Syria. Here,
Berriman, Matthew, Beverley, Stephen M., Cotton, James A., Durrant, Caroline, Grigg, Michael E., Iantorno, Stefano A., Khan, Asis, Myler, Peter, Ouellette, Marc, Sacks, David L., Sanders, Mandy J., Warren, Wesley C., Weiss, Louis M.   +12 more
core   +3 more sources

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, EarlyView.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

RTS,S/AS02 and the quest of the Holy Grail [PDF]

, 2002
High-profile programs under the WHO/Roll Back Malaria initiative, in addition to unravelling the human and malaria parasite genomes, have ensured that malaria vaccine research and development are enjoying an unprecedented boom. So far, the development of
Reithinger, R
core  

Control of mucocutaneous leishmaniasis, a neglected disease: results of a control programme in Satipo Province, Peru. [PDF]

, 2005
Mucocutaneous leishmaniasis (MCL) is an important health problem in many rural areas of Latin America, but there are few data on the results of programmatic approaches to control the disease.
Alvarez, E, Arlt, D, Bertoletti, G, Conte, M, de Jesus Sanchez, J, Fournier, C, Garcia, L M L, Guthmann, J P, Huari, R, Llanos-Cuentas, A, Lonlas, S, Rosales, M, Torreele, E   +12 more
core   +2 more sources

Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids [PDF]

, 2020
This is the pre-peer reviewed version of the following article: Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids, which has been published in final form at https://doi.org/10.1002/slct.201903835.
Carda, Miguel, Cardona G, Wilson I, Coa, Juan Carlos, Conesa Milián, Laura, Robledo, Sara M., Upegui Zapata, Yulieth Alexandra, Yepes, Andrés   +6 more
core   +1 more source

Plasma levels of interlukin-4 and Interferon- in patients with chronic or healed cutaneous leishmaniasis [PDF]

Iranian Journal of Basic Medical Sciences, 2014
Objective(s):In this study, the serum level of interferon-γ (IFN- γ) and interlukin-4 (IL-4) was evaluated as a marker of Th1 and Th2 immune response that influence the clinical course of cutaneous leishmaniasis[r1] .
Ahmad Reza Taheri, Vahid Mashayekhi Goyonlo, Yalda Nahidi, Nasrin Moheghi, Jalil Tavakkol Afshari   +4 more
doaj  

Comparison of Oral Zinc Sulfate with Systemic Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis

Dermatology Research and Practice, 2011
The purpose of this study was to investigate comparison between oral zinc sulfate and meglumine antimoniate in the treatment of cutaneous leishmaniasis (CL). So 100 patients with CL were included and randomly divided into two groups.
Mohamad Javad Yazdanpanah, Mahnaz Banihashemi, Fakhrozaman Pezeshkpoor, Mohammad Khajedaluee, Sororozaman Famili, Iman Tavakoli Rodi, Hadis Yousefzadeh   +6 more
doaj   +1 more source

Localization of Lupoid Leishmaniasis on the face: A case control study

JEADV Clinical Practice
Background In Lupoid Leishmaniasis, erythematous to brown papules often occur around a central old scar, which can expand over time. For unclear reasons, these lesions tend to develop on the facial area.
Mohammad J. Yazdanpanah, Rosita Moradpour, Ahmad R. Taheri, Habibollah Esmaily, Omalbanin Afroushteh   +4 more
doaj   +1 more source