Results 91 to 100 of about 40,625 (298)
Multigene Next-Generation Sequencing Panel Identifies Pathogenic Variants in Patients with Unknown Subtype of Epidermolysis Bullosa: Subclassification with Prognostic Implications [PDF]
, 2017 Purpose: Epidermolysis bullosa (EB), the prototype of heritable blistering diseases, is caused by mutations in as many as 19 distinct genes. In this study, we evaluated the molecular basis of EB in 93 families, many of them of unknown subtype. Methods:
Abiri, Maryam +15 more
core +1 more source
Journal of Medical Case Reports, 2011 Introduction The monoclonal anti-vascular endothelial growth factor antibody bevacizumab is increasingly used in the treatment of several malignant tumors. The usual side effects of this drug are hypertension and proteinuria. Paclitaxel is widely used in
Koulu Leena +4 more
doaj +1 more source
COMO: A Pipeline for Multi-Omics Data Integration in Metabolic Modeling and Drug Discovery [PDF]
arXiv, 2020 Identifying potential drug targets using metabolic modeling requires integrating multiple modeling methods and heterogenous biological datasets, which can be challenging without sophisticated tools. We developed COMO, a user-friendly pipeline that integrates multi-omics data processing, context-specific metabolic model development, simulations, drug ...
arxiv
Not just skin deep: reframing chronic inflammatory skin disease as a systemic threat
Internal Medicine Journal, EarlyView.Abstract Chronic inflammatory skin disease is more than skin deep, with several cutaneous disease entities associated with an increased risk of cardiovascular disease. Notably, psoriasis carries a markedly increased risk of cardiovascular disease, along with a significant comorbid burden.
Annika Smith, Clara K. Chow
wiley +1 more source
Autologous Fat Transfer in a Patient with Lupus Erythematosus Profundus
Case Reports in Dermatology, 2012 Lupus erythematosus profundus, a form of chronic cutaneous lupus erythematosus, is a rare inflammatory disease involving in the lower dermis and subcutaneous tissues. It primarily affects the head, proximal upper arms, trunk, thighs, and presents as firm
Jimi Yoon +5 more
doaj +1 more source
Optics-less smart sensors and a possible mechanism of cutaneous vision in nature [PDF]
, 2008 Optics-less cutaneous (skin) vision is not rare among living organisms, though its mechanisms and capabilities have not been thoroughly investigated. This paper demonstrates, using methods from statistical parameter estimation theory and numerical simulations, that an array of bare sensors with a natural cosine-law angular sensitivity arranged on a ...
arxiv +1 more source
Journal of the European Academy of Dermatology and Venereology, EarlyView.This study identifies interferons as key mediators in lichenoid chronic GVHD pathogenesis, along with Th2 and Th17 involvement. It particularly highlights the role of Type I interferon, showing that early anti‐IFNAR1 treatment reduces skin inflammation in a murine model of chronic cutaneous GVHD.
Chloé Grolleau +11 more
wiley +1 more source
Effects of mycophenolate mofetil on cutaneous lupus erythematosus in (NZB × NZW) F1 mice [PDF]
, 2006 BackgroundFew studies have evaluated the effects and precise molecular mechanism of mycophenolate mofetil (MMF) in the treatment of human cutaneous lupus erythematosus (CLE). Our findings shed light on the therapeutic effects of MMF in a UVB-induced NZB ×
Lee, Yen-Feng +6 more
core +2 more sources
Lupus Erythematosus: Cutaneous Manifestations and Treatment
Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2019 Cutaneous lupus erythematosus (CLE) includes a broad range of dermatologic manifestations, which may or may not be associated with systemic manifestations. Specific CLE - defined by the presence of an interface dermatitis on histopathological evaluation -
Francisca Alves, Margarida Gonçalo
doaj +1 more source