Results 21 to 30 of about 66,815 (211)

Nivolumab induced vitiligo-like depigmentation in metastatic acral lentiginous melanoma

Pigment International, 2019
Melanoma is an uncommon malignancy in Indian subcontinent. Dermoscopy of cutaneous metastases of malignant melanoma has been rarely reported. Immune checkpoint inhibitors are increasingly being used for management of metastatic melanoma.
Disha Dabbas, Shekhar Neema, Niloy Pathak   +2 more
doaj   +1 more source

Resection of a Recurrent Metastatic Leptomeningeal Melanoma: Case Report and Literature Review

Interdisciplinary Neurosurgery, 2023
Malignant melanoma is considered the most aggressive among all cutaneous cancer. Malignant melanoma commonly causes cerebral metastasis. The survival rate of melanoma with cerebral metastases is considerably poor.
Nyoman Golden, Marleen, Made Bhuwana Putra, Marthinson Andrew Tombeng, I Gusti Ngurah Dharma Kesuma, Denny Japari, Ni Putu Sriwidyani, Yosi Wanda Kusuma, Jevon Indra Susanto   +8 more
doaj   +1 more source

Regression of cutaneous squamous cell carcinoma after the development of pembrolizumab‐induced bullous pemphigoid

JEADV Clinical Practice, 2023
Bullous pemphigoid is a rare complication of immune checkpoint inhibitor treatment. We report a case of pembrolizumab‐induced bullous pemphigoid in a patient with malignant melanoma and concomitant cutaneous squamous cell carcinoma that regressed.
Shin Iinuma, Kei Hayashi, Akemi Ishida‐Yamamoto   +2 more
doaj   +1 more source

Cutaneous malignant melanoma in situ: A Danish cross-sectional study on patient and tumour characteristics in 144 cases

JPRAS Open, 2015
Introduction: Cutaneous malignant melanoma in situ (MIS) has not been subject to much attention or investigation. Little is known of the characteristics of patients and tumours.
Anders Klit, Cecilie Brandt Lassen, Caroline Holkmann Olsen, Jørgen Lock-Andersen   +3 more
doaj   +1 more source

Case report: Type 2 diabetes mellitus with plantar malignant melanoma: Report of two cases

Frontiers in Oncology, 2023
Malignant melanoma is a highly malignant tumor that originates from melanocytes. It has a poor prognosis and rarely occurs on the foot. Diabetic foot ulcer is one of the most serious chronic complications of diabetes. This paper reports two cases of type
Bi-Ling Huang, Bi-Ling Huang, Min Tan, Min Tan, Ming-Liu Li, Ming-Liu Li, Yuan-Yuan Teng, Yuan-Yuan Teng, Min Zhou, Min Zhou, Min Wang, Min Wang   +11 more
doaj   +1 more source

Cutaneous horn malignant melanoma

Dermatology Reports, 2013
A 73-year-old Japanese woman presented with cutaneous horn on the right cheek. The resected tumor was 9 mm in diameter, with 14 mm protrusion, and showed exophytic growth with marked papillomatosis.
Haruto Nishida, Tsutomu Daa, Kenji Kashima, Motoki Arakane, Hiromitsu Shimada, Mizuki Goto, Yoshitaka Kai, Yutaka Hatano, Osamu Okamoto, Shigeo Yokoyama   +9 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Diagnostic challenge for ovarian malignant melanoma in premenopausal women: Primary or metastatic?

World Journal of Surgical Oncology, 2011
Background In the ovary, metastatic malignant melanoma may be confused with primary malignant melanoma and presents a diagnosis challenge. Most cases are associated with disseminated diseases and poor prognosis.
Kharmoum Saoussan, Essaidi Ismail, Oukabli Mohamed, Kadiri Habiba, Fadoukhair Zouhour, Sbitti Yassir, M'rabti Hind, Albouzidi Abderrahmane, Ichou Mohammed, Errihani Hassan   +9 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source