Results 31 to 40 of about 809,107 (265)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Clinical Significance of Plasma D-Dimer in COVID-19 Mortality

Frontiers in Medicine, 2021
It is not clear whether D-dimer can be an independent predictor of coronavirus disease 2019 (COVID-19) mortality, and the cut-off of D-dimer for clinical use remains to be determined.
Yayun Li, Yayun Li, Yuhao Deng, Lin Ye, Lin Ye, Huiyan Sun, Huiyan Sun, Songtao Du, Huining Huang, Huining Huang, Furong Zeng, Furong Zeng, Furong Zeng, Xiang Chen, Xiang Chen, Guangtong Deng, Guangtong Deng   +16 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Cinétique de la troponine Ic et valeurs seuils pour le diagnostic d'infarctus du myocarde après chirurgie cardiaque sous circulation extracorporelle

The Pan African Medical Journal, 2012
INTRODUCTION: L'objectif de ce travail était d'étudier la cinétique de la Troponine Ic (TnIc) après chirurgie cardiaque sous circulation extracorporelle (CEC) et établir des valeurs seuils de TnIc pour le diagnostic d'infarctus du myocarde (IDM) post ...
Samy Kallel, Anwar Jarraya, Maged Ellouze, Imed Frikha, Abbdelhamid Karoui   +4 more
doaj   +1 more source

Pharmacodynamic Target Assessment and PK/PD Cutoff Determination for Gamithromycin Against Streptococcus suis in Piglets

Frontiers in Veterinary Science, 2022
Gamithromycin is a long-acting azalide antibiotic that has been developed recently for the treatment of swine respiratory diseases. In this study, the pharmacokinetic/pharmacodynamic (PK/PD) targets, PK/PD cutoff, and optimum dosing regimen of ...
Rui-Ling Wang, Rui-Ling Wang, Ping Liu, Ping Liu, Xiao-Feng Chen, Xiao-Feng Chen, Xin Yao, Xin Yao, Xiao-Ping Liao, Xiao-Ping Liao, Xiao-Ping Liao, Ya-Hong Liu, Ya-Hong Liu, Ya-Hong Liu, Jian Sun, Jian Sun, Jian Sun, Yu-Feng Zhou, Yu-Feng Zhou, Yu-Feng Zhou   +19 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Recognizing ALBI Grade in Child-Pugh A Patients at a Glance: Mathematical Simulation and Large-Scale Clinical Validation

Diagnostics
Background: The albumin–bilirubin (ALBI) grade provides an objective assessment of hepatic reserve, but the need for calculation by means of a formula has hampered its use at the bedside.
Po-Heng Chuang, Yuan-Jie Ding, Chih-Yun Lin, Sheng-Nan Lu   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Enhanced independent discriminative performance of elevated lipoprotein(a) for cardiovascular outcomes in patients with diabetes: a comparative analysis of optimal cutoff values

Frontiers in Endocrinology
ObjectiveThis study aimed to evaluate the independent discriminative performance of elevated Lipoprotein(a) [Lp(a)] in identifying prevalent cardiovascular disease (CVD), specifically in patients with Diabetes Mellitus (DM), and to determine the optimal ...
Song Wen, Yanju He, Xiucai Li, Zhimin Xu, Dan Liu, Jiyu Li, Ligang Zhou   +6 more
doaj   +1 more source

The radial cutting torch device application due to drill string sticking [PDF]

Podzemni Radovi, 2016
Stuck pipe is a common problem with tremendous impact on drilling efficiency and costs in the oil industry. Generally, the stuck pipe troubles are solved after their occurrences by using some standard operational procedures such as working the drill ...
Leković Branko, Šumar Nenad, Karović-Maričić Vesna, Danilović Dušan   +3 more
doaj   +1 more source