Results 101 to 110 of about 64,436 (298)
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
An Experimental and Numerical Simulation Study on Rock Cutting Based on Pre-Breaking
Shiyou jixie, 2019 The design of the mixed-cutter placement can only rely on the engineering experience. The combination of experiment and numerical simulation is used to study the rock breaking force and rock breaking efficiency of the PDC cutter under different pre ...
Liu Zhong, Hou Huihui, Hu Wei
doaj
The Characteristic of Cutting Head in Marine Gas Hydrate by Cutter Suction Exploitation
工程科学与技术, 2016 :Abstract:The flow filed model of cutter-suction was established according to the structure and working principle of cutting head.The characteristic of flow filed was researched by utilizing Computational fluid dynamics theory and Fluent simulation ...
xu hailiang +3 more
doaj
Aging and Cancer, EarlyView.This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source
Jixie chuandong, 2007 CAD/CAM of form milling cutter of gear based on Manufacture Engineer（ME） improves the precision of cutter edge curve and manufactured gears, and prolongs the life of cutter.
包耳, 康晶, 邵强
doaj
Aging and Cancer, EarlyView.In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara +3 more
wiley +1 more source
Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source
Geometry and Simulation of the Generation of Cylindrical Gears by an Imaginary Disc Cutter
, 2014 [[abstract]]This paper proposed a method of representing the geometry of an imaginary disc cutter in parameter form. The undercutting condition of the imaginary disc cutter is studied, and the mathematical model of the generated gears is developed by the
Yang, Shyue-Cheng; Liang, Tsang-Lang
core
LubricantsThe large-diameter slurry tunnel boring machine (TBM) is widely used in the construction of tunnels across rivers and seas. However, cutter wear has become a critical issue that severely limits the tunnelling efficiency.
Yingran Fang +4 more
doaj +1 more source