Results 111 to 120 of about 1,349,956 (360)

Double arc instability in the solar corona [PDF]

open access: yes, 2017
The stability of the magnetic field in the solar corona is important for understanding the causes of solar eruptions. Although various scenarios have been suggested to date, the tether-cutting reconnection scenario proposed by Moore et al.(2001) is one ...
73596, 73597, Ishiguro, N., Kusano, K.
core   +2 more sources

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

Multi-Objective Optimization of Abrasive Cutting Process Conditions to Increase Economic Efficiency

open access: yesTechnologies
Existing studies on the abrasive cutting process have primarily focused on the influence of cutting conditions on key parameters such as temperature, cut-off wheel wear, and machined surface quality.
Irina Aleksandrova
doaj   +1 more source

Surface microhardening studies on steels after high feed milling [PDF]

open access: yes, 2018
The paper deals with the impact of high-speed machining production methods on the integrity of component surfaces. One has to point out that cutting conditions during machining have a significant impact on the final properties of surface and subsurface ...
Petrů, Jana   +3 more
core   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

Performance comparison and prediction of cutting energy of new cemented carbide micro-pit turning tool

open access: yes工程科学学报, 2017
Cutting energy can be transformed into cutting heat, which directly affects the cutting temperature. Therefore, it is important to understand the generation, transfer, and transformation of cutting energy to cutting temperature.
ZHAN Gang   +3 more
doaj   +1 more source

Using the Finite Element Method to Determine the Temperature Distributions in Hot-wire Cutting. [PDF]

open access: yes, 2011
Hot-wire cutting is a common material removal process used to shape and sculpt plastic foam materials, such as expanded polystyrene (EPS). Due to the low cost and sculpt-ability of plastic foams they are popular materials for large sized (> 1 m³ ...
Aitchison, David   +1 more
core  

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

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