Results 171 to 180 of about 1,424,201 (360)

Towards self-optimizing and self-adaptive milling processes [PDF]

This paper presents a novel control architecture system which is composed of a multi-objective cost function which Pareto optimises the programming of cutting parameters while adapting the milling process to new cutting conditions if new constraints ...
Fletcher, Simon, Longstaff, Andrew P., Myers, Alan, Rubio Rodriguez, Luis   +3 more
core  

Investigating the performance of TiN and TiAIN coatings on milling cutter used for machining bimetal steel strip [PDF]

, 2009
Surface engineering of cutting tools (single point or multipoint) through advanced coatings (e.g., TiN) has contributed towards considerable improvement of tool life, productivity and machining quality [1] by modifying the tool substrate.
Haider, Julfikar, Sarwar, Mohammed
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Cutting edge condition diagnostics during hobbing [PDF]

Mechanik, 2016
Jan Burek, Robert Babiarz, Paweł Sułkowicz, Jarosław Buk   +3 more
openaire   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Experimental Investigation and Statistical Evaluation of Optimized Cutting Process Parameters and Cutting Conditions to Minimize Cutting Forces and Shape Deviations in Al6026-T9. [PDF]

Materials (Basel), 2020
Abas M, Salah B, Khalid QS, Hussain I, Babar AR, Nawaz R, Khan R, Khan R, Saleem W, Saleem W.   +9 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Investigation of cutting conditions on tool life in shoulder milling of Ti6Al4V using PVD coated micro-grain carbide insert based on design of experiments. [PDF]

Heliyon, 2020
Tatar K, Sjöberg S, Andersson N.
europepmc   +1 more source

Surface Grinding of Ti-6Al-4V Alloy with SiC Abrasive Wheel at Various Cutting Conditions

, 2017
AntonioVitor de Mello, Rosemar Batista de Silva, Álisson Rocha Machado, Rogério Valentim Gelamo, Anselmo Eduardo Diniz, Rodolfo Fischer Moreira de Oliveira   +5 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source