Results 51 to 60 of about 1,424,201 (360)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Evaluation of Cutting Forces and Temperatures in Micro-Milling of NiTi Alloys Using Finite Element Modeling

Журнал інженерних наук
Today, micro-milling of NiTi alloys is used to manufacture precision mechanisms, instrumentation, space technology, micro-electro-mechanical systems, biomedical devices, and implants. It is becoming increasingly widespread.
Nataliia Balytska, Oleh Tomashevskyi, Valentina Shadura   +2 more
doaj   +1 more source

Research on Conventional and High-Speed Machining Cutting Force of 7075-T6 Aluminum Alloy Based on Finite Element Modeling and Simulation

Metals, 2022
In current industrial practice, the finite element modeling of the metal cutting process is essential. In this paper, finite element analysis of conventional and high-speed cutting of 7075-T6 aluminum alloy is carried out.
Zhijie Wang, Yan Cao, Sergey Gorbachev, Victor Kuzin, Weiliang He, Junde Guo   +5 more
doaj   +1 more source

On conditional cuts for stochastic dual dynamic programming

EURO Journal on Computational Optimization, 2020
26 pages, 10 ...
W. van Ackooij, X. Warin
openaire   +3 more sources

Surface roughness modeling of CBN hard steel turning [PDF]

, 2018
Study in the paper investigate the influence of the cutting conditions parameters on surface roughness parameters during turning of hard steel with cubic boron nitrite cutting tool insert. For the modeling of surface roughness parameters was used central
Ješić, D., Kovač, P., Nedic, B., Rodić, D., Savković, B., Taric, M.   +5 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Machining stability and machine tool dynamics [PDF]

, 2007
Machining is a common manufacturing process in industry due to its high flexibility and ability to produce parts which excellent quality. The productivity and quality in machining operations can be limited by several process constraints one of which is ...
Budak, Erhan
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The Choice of Optimal Cutting Conditions, Taking into Account the Quality of the Machined Surface of the Part on the Roland MDX20 Milling Machine

RUDN Journal of Engineering Research
The results of optimizing the milling process on the Roland MDX-20 machine are presented: the maximum allowable and optimal cutting conditions for parts made of foam, hard and soft modeling plastics, and hardwood are empirically established. At the first
Dmitry G. Allenov, Nadezhda A. Yakovleva, Kristina B. Deinova, Danila V. Danilov, Matvey V. Azanov   +4 more
doaj   +1 more source