Results 71 to 80 of about 8,660,062 (300)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Numerical and analytical modeling of orthogonal cutting : The link between local variables and global contact characteristics [PDF]

, 2011
The response of the tool–chip interface is characterized in the orthogonal cutting process by numerical and analytical means and compared to experimental results. We study the link between local parameters (chip temperature, sliding friction coefficient,
Miguélez Garrido, María Henar, R. Cheriguene, MOLINARI, Alain, CHERIGUENE, Rachid, MIGUELEZ, Henar, A. Molinari, Molinari, A., H. Miguelez   +7 more
core   +1 more source

A Review of Insights and Research Progress on Hard Turning

Annals of "Dunarea de Jos" University of Galati, Fascicle XII, Welding Equipment and Technology
Of late, due to the launch of improved machine tool designs and extremely hard cutting tools, “Hard Turning” (HT) or “Hard Finish Turning” (HFT) has turned out to be an innovative, cost-effective, and smart alternative to the traditional grinding and ...
S. Girisankar, S. Senthil Murugan, E. Shankar   +2 more
doaj   +1 more source

In-Process Chatter Detection in Surface Grinding

MATEC Web of Conferences, 2015
The chatter causes the poor surface finish during the surface grinding. It is therefore necessary to monitor the chatter during the process. Hence, this research has proposed the in-process chatter detection in the surface grinding process by utilizing ...
Tangjitsitcharoen Somkiat, Senjuntichai Angsumalin   +1 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Cutting Force in Stone Machining by Diamond Disk

Advances in Materials Science and Engineering, 2010
Stone machining by diamond disk is a widespread process to manufacture standard products, such as tiles, slabs, and kerbs. Cutting force and energy may be used to monitor stone machining.
S. Turchetta
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Compression and crevasses in vitreous sections under different cutting conditions. [PDF]

, 2008
Compression and crevasses are common cutting artefacts in cryo-ultramicrotomy of vitreous sections. They can be reduced or suppressed under optimal cutting conditions.
Dubochet, J., Han, H.M., Zuber, B., Zuber, Benoît, Han, H-M, Dubochet, J, Dubochet J, Han HM, Zuber B   +8 more
core   +1 more source

A Pre-Study of the Relationship Between Machining Technology Parameters and Surface Roughness in the Scope of the Optimal Cost Efficiency of Machining

Engineering Proceedings
This research investigates the relationship between machining technology parameters and surface roughness to optimize the cost efficiency of machining processes.
László Pálfi, József Beke, Szabolcs Szalai   +2 more
doaj   +1 more source