From omics to AI—mapping the pathogenic pathways in type 2 diabetes
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan+2 more
wiley +1 more source
Traverse Grinding of X6CrNiMoTi Steel and its Final Surface Quality for Giving Cutting Conditions
Machining of stainless steels is often an important used technology. Products made from these materials are often used in mechan-ical engineering and the quality of workpiece surface roughness after machining respective grinding is one of the important ...
Nataša Náprstková+2 more
doaj
Atomistic aspects of ductile responses of cubic silicon carbide during nanometric cutting [PDF]
Cubic silicon carbide (SiC) is an extremely hard and brittle material having unique blend of material properties which makes it suitable candidate for microelectromechanical systems and nanoelectromechanical systems applications.
Goel, Saurav+4 more
core +2 more sources
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen+2 more
wiley +1 more source
A polyhedral approach for the Equitable Coloring Problem [PDF]
In this work we study the polytope associated with a 0,1-integer programming formulation for the Equitable Coloring Problem. We find several families of valid inequalities and derive sufficient conditions in order to be facet-defining inequalities.
Bahiense+15 more
core +2 more sources
Conditional Drilling of a Sand Cut by a Fault [PDF]
This paper discusses the Bayesian updating of the chances of hydrocarbon success in a sand cut by a fault when the sand is charged after fault time. Prior to actual drilling the decision to drill either the downthrown sand component or the upthrown sand component depends, in particular, on whether the fault is considered to be leaking a lot or a ...
openaire +1 more source
Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász+6 more
wiley +1 more source
A Review of Insights and Research Progress on Hard Turning
Of late, due to the launch of improved machine tool designs and extremely hard cutting tools, “Hard Turning” (HT) or “Hard Finish Turning” (HFT) has turned out to be an innovative, cost-effective, and smart alternative to the traditional grinding and ...
S. Girisankar+2 more
doaj +1 more source
Cutting Force in Stone Machining by Diamond Disk
Stone machining by diamond disk is a widespread process to manufacture standard products, such as tiles, slabs, and kerbs. Cutting force and energy may be used to monitor stone machining.
S. Turchetta
doaj +1 more source
Modelling and simulation of the dynamic cutting process and surface topography generation in nano/micro cutting [PDF]
In nano/micro cutting process, the surface quality is heavily dependent on all the dynamic factors in machining including those from the material, tooling, cutting parameters, servo accuracy, mechanical structure deformation, and non-linear factors as ...
Cheng, K, Zhou, L
core