Results 31 to 40 of about 114,649 (262)

Experimental Study on Conglomerate Breaking Characteristics of Conical PDC Cutter

Shiyou jixie, 2021
In order to further improve the rock breaking efficiency and the adaptability of drilling hard and complex strata of PDC bit, a comprehensive test device of rock breaking by PDC cutter was developed. The test device was used to conduct experimental study
Xu Weiqiang, Shi Huaizhong, Cao Quan, Shi Xingxing, Hu Xihui, Xiong Chao, Chen Han   +6 more
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Cutting-Edge Techniques for Depth Map Super-Resolution

CoRR, 2023
To overcome hardware limitations in commercially available depth sensors which result in low-resolution depth maps, depth map super-resolution (DMSR) is a practical and valuable computer vision task. DMSR requires upscaling a low-resolution (LR) depth map into a high-resolution (HR) space. Joint image filtering for DMSR has been applied using spatially-
Ryan Peterson 0005, Josiah Smith
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Finite element simulation of high-speed finish milling of SKD11 hardened steel based on modified constitutive equation

Cogent Engineering, 2018
High precision parts have been widely used in automobile, aerospace, medical and other fields. Conventional machining methods are difficult to meet the requirements of the high-quality requirements of components, including shape precision, dimensional ...
Tang Dewen, Peng Cong, Zhang Jiayu
doaj   +1 more source

Cutting Force and Cutting Quality during Tapered Milling of Glass Magnesium Board

Applied Sciences, 2019
In this paper, the effects of tool geometry and cutting parameters on cutting force and quality were investigated during the tapered milling of glass magnesium (MGO) board with diamond cutters. The results were as follows: firstly, both the cutting force
Pingxiang Cao, Zhaolong Zhu, Xiaolei Guo, Xiaodong (Alice) Wang, Chunchao Fu, Chi Zhang   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Study on cutting force of turning of 27SiMn steel based on orthogonal experiment

Journal of Hebei University of Science and Technology, 2015
In order to explore the cutting laws of difficult-to-machine material 27SiMn steel, an orthogonal method is employed in its cutting experiment by using carbide tool.
Liangbao LIU, Jianfei SUN, Wuyi CHEN, Wei WANG   +3 more
doaj   +1 more source