Results 51 to 60 of about 798,333 (309)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Evaluation of Surface Quality and Productivity in Conventional Milling of Copper Beryllium Using Minimum Quantity Lubrication

Tribology in Industry
Copper Beryllium (C17200) has ideal physical and mechanical properties of high fatigue strength, thermal conductivity, and hardness, making the alloy ideal for various high-reliability applications in aerospace, producing inserts and tooling for ...
Ken N. Mwangi, Job Wambua, Fredrick M. Mwema, James M. Wakiru, Tien-Chien Jen   +4 more
doaj   +1 more source

Micro-orthogonal Cutting of Metals [PDF]

, 2008
Collaboration avec l'EPFLHigh speed micromilling with single point or multi-edge cutting tools of diameters smaller than 300 m is finding increasing applications for the production of small very precise metallic parts.
AGEBEBIADE, Kossi, FROMENTIN, Guillaume, GIOVANOLA, Jacques, KERMER, Daniel, LOUTAN, Olivier   +4 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Study on cutting force of turning of 27SiMn steel based on orthogonal experiment

Journal of Hebei University of Science and Technology, 2015
In order to explore the cutting laws of difficult-to-machine material 27SiMn steel, an orthogonal method is employed in its cutting experiment by using carbide tool.
Liangbao LIU, Jianfei SUN, Wuyi CHEN, Wei WANG   +3 more
doaj   +1 more source

Method and tool for machining a transverse slot about a bore [PDF]

, 1980
A method and apparatus for cutting a transverse slot about a bore of smaller diameter than that of the slot are disclosed. The invention consists of introducing a cutting head facing transversely to the bore, through the bore opening its distance from ...
David-Malig, M. A.
core   +1 more source

A response surface methodology and desirability approach for predictive modeling and optimization of cutting temperature in machining hardened steel [PDF]

, 2014
This paper presents an experimental investigation on cutting temperature during hard turning of EN 24 steel (50 HRC) using TiN coated carbide insert under dry environment.
Ashok Kumar Sahoo, Purna Chandra Mishra
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Shearer parameter optimization and low energy consumption mining based on 3D point cloud characterization of coal wall

Energy Science & Engineering
To achieve efficient and low energy consumption mining under different cutting depths of a shearer, a multiparameter coupling optimization method for the shearer based on three‐dimensional (3D) characterization of the coal wall was proposed.
Haijian Wang, Xingrui Fan, Mengdie Huang
doaj   +1 more source

Influence of Cutting Fluid Flow Rate and Cutting Parameters on the Surface Roughness and Flank Wear of TiAlN Coated Tool In Turning AISI 1015 Steel Using Taguchi Method

Archives of Metallurgy and Materials, 2017
This paper presents the influence of cutting parameters (Depth of cut, feed rate, spindle speed and cutting fluid flow rate) on the surface roughness and flank wear of physical vapor deposition (PVD) Cathodic arc evaporation coated TiAlN tungsten carbide
Moganapriya C., Rajasekar R., Ponappa K., Venkatesh R., Karthick R.   +4 more
doaj   +1 more source