Results 141 to 150 of about 121,508 (306)
, 2014 Researches have shown the cutting parameters and the burrs formation are close related, but these relationships cannot be formed in a simple formula. The mechanism of burrs formation and its appearance occurred to the cutting material quite depends on ...
Tseng, P.C., 曾柏昌, Chiou, I.C.
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
A cut finite element method for the Biot system of poroelasticity
CoRRWe propose a novel cut finite element method for the numerical solution of the Biot system of poroelasticity. The Biot system couples elastic deformation of a porous solid with viscous fluid flow and commonly arises on domains with complex geometries that make high-quality volumetric meshing challenging.
Nanna Berre +3 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Investigation of Material Removal Mechanism in Grinding: A Single Grit Approach
This thesis has investigated material removal mechanisms in grinding by considering single grit workpiece interaction. The investigation was performed both experimentally and using finite element simulation.
Opoz, Tahsin Tecelli
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Fly-Cutting Processing of Micro-Triangular Pyramid Arrays and Synchronous Micro-Scrap Removal
MicromachinesMany micro-scraps are generated when a micro-triangular pyramid array (MTPA) is machined by the fly-cutting method. Micro-scraps are generally not removed quickly enough; therefore, these residual micro-scraps participate in the cutting process again ...
Jiashun Gao +3 more
doaj +1 more source
Finite element mechanical analysis of civil cutting tools for bone cutting
Journal of Physics: Conference SeriesAbstract By conducting finite element analysis on the process of bone cutting using Ansys, it was found that the cutting edge angle and cutting speed of different material tools have a significant impact on the performance of the workpiece and tool.
Weigui Zhai +3 more
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Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Surface hardening of cutting elements agricultural machinery vibro arc plasma
, 2020 At present, the state technical policy aimed at the modernization of worn equipment, including agriculture, based on the use of high-performance technology called nanotechnology.
Adigamov N. +3 more
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