Results 121 to 130 of about 121,508 (306)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Bases of variational method for calculating of metal-cutting systems accuracy

MATEC Web of Conferences, 2018
The bases of a variation method to calculate the metal-cutting systems accuracy for the first time are systemically stated in this paper. The main attention is paid to a problem of joint influence of geometrical accuracy of machine tools and cutting ...
Anikeeva Olesya, Ivakhnenko Alexander, Erenkov Oleg   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Stress-Strain State and Damage of Tribo-Fatigue System Clamp-Knife-Base of Harvester Cutting Instrument

Механика машин, механизмов и материалов, 2012
Multicomponent clamp-knife-base system of cutting instrument of a harvester is considered. Stress-strain and damage states of the system are calculated in two-dimensional statement.
S.S. Scherbakov
doaj  

Finite Element Studies in Metal Cutting

, 2003
AdvantEdge is a finite element software package that integrates advanced dynamics, thermo-mechanically coupled finite element numerics and material modelling appropriate for machining processes. AdvantEdge allows users to specify the workpiece material, tool geometry and cutting conditions.
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Evaluation of Cutting Forces and Temperatures in Micro-Milling of NiTi Alloys Using Finite Element Modeling

Today, micro-milling of NiTi alloys is used to manufacture precision mechanisms, instrumentation, space technology, micro-electro-mechanical systems, biomedical devices, and implants. It is becoming increasingly widespread.
Shadura, V.A., Oleh Tomashevskyi, Valentina Shadura, Balytska, N.O., Tomashevskyi, O.O., Nataliia Balytska   +5 more
core   +1 more source

Improvement of face mill design for finishing flat surface parts

Технічна інженерія
The quality machined surface parts depends on the kinematics cutting process, the processing mode, structural and geometric parameters of the cutting tool, etc.
H.M. Vyhovskyi, M.M. Plysak, L.Ye. Hlembotska, A.V. Golubovskyi   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Bucket wheel excavator cutting tooth stress and deformation analysis during operation using Finite Elements Method (FEM)

, 2018
In the case of bucket wheel excavators, the cutting process is influenced by the forces opposing the working elements and cutting tools. These forces determine the choice of machines and their parameters as well as the operating method [1, 2].
Rebedea, N. I., Brinas, I. K., Oltean, I. L.   +2 more
core   +1 more source