Results 101 to 110 of about 121,508 (306)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Behaviour of polymeric materials in machining [PDF]

open access: yes
The machining characteristics of a glassy thermoplastic (Polyvinyl Chloride) and a semi-crystalline thermoplastic (High Density Polyethylene) have been studied.
Kim, Yong-hwan, Ph.D.
core  

Melhoria do processo de furação de ferro fundido cinzento com brocas helicoidais de metal-duro [PDF]

open access: yes, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Mecânica, Florianópolis, 2014.A furação é um dos processos mais utilizados dentre os processos de fabricação com ferramentas de ...
Pimentel, Ricardo
core  

Studies on the selected properties of C45 steel elements surface layer after laser cutting, finishing milling and burnishing [PDF]

open access: yes, 2016
The article presents the results of studies on surface roughness and microhardness of C45 steel elements after laser cutting, and then finishing milling or burnishing.
Skoczylas, A., Zaleski, K.
core   +1 more source

Dynamics of wear of the cutting elements of tillers

open access: yes, 2015
Dynamics of wear of the cutting elements of tillers. The paper discusses theoretical studies of wear of the cutting elements of working bodies of tillers to develop their technological process of hardening, providing on the one hand increase ...
Пасюта, Андрій Григорович   +4 more
core   +1 more source

Evolution of Seal Cutting Symbol Elements [PDF]

open access: yesProceedings of the 2016 International Conference on Arts, Design and Contemporary Education, 2016
Seal cutting is a traditional art and it is the predecessor of one of the four inventions-printing which closely combined with the calligraphy, so far it has 3000 years of history. Also it is the prototype of Chinese logo design so its cultural status can not be ignored.
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

A Finite Element Modeling of Orthogonal Cutting

open access: yesEngineering review, 1997
A finite element model of orthogonal metal cutting is described. The proposed model is based on an updated Lagrangian formulation for plane strain conditions and employs an elastic-plastic material model.
openaire   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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