Results 111 to 120 of about 121,508 (306)

Enhancing the Digital Inheritance and Development of Chinese Intangible Cultural Heritage Paper-Cutting Through Stable Diffusion LoRA Models

Applied Sciences
With the advent of artificial intelligence digitization, intangible cultural heritage faces challenges in preservation and transmission. Utilizing modern technology to achieve digital protection and dissemination has become a crucial issue today.
Mengge Dai, Yuhao Feng, Runqi Wang, Jungho Jung   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Constitutive behavior study of copper alloy under cold and hot compression conditions towards LN2 assisted cutting [PDF]

New standards are being introduced to eliminate toxic elements in materials. For instance, copper alloys should no longer contain lead, although this makes them more challenging to machine.
GERMAIN, Guénaël, ZHANG, Jun, LI, Baochen, AYED, Yessine   +3 more
core   +1 more source

Technoeconomic and thermodynamic aspects of the edge cutting machining optimization

Advanced Engineering Research, 2016
The investigation objective is to develop a calculation method of selecting the optimum cutting speed corresponding to the minimum tool-wear rate. The analysis of the known optimization criteria such as tribological, thermal, energy and thermodynamic ...
Anatoliy A. Ryzhkin, Juliya A. Oleynikova, Denis V. Moiseev, Evgeniy V. Fominov   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Software Control of Machines Based on Typification of Transient Zone Parameters for Processing of Original Non-Circular Parts

Механика машин, механизмов и материалов
The paper provides an overview of trends in the preparation of control programs for CNC metal cutting machines. The direction in the development of programming of machining parts based on the transient zone parameter typification is described.
Nikolay N. Popok, Nikolay V. Belyakov, Stanislav K. Seleznev   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Impacts of elevated CO2 and partial defoliation on mineral element composition in rice

Frontiers in Plant Science
IntroductionThis study explores how elevated CO2 concentration may alter the source-sink dynamics in rice by providing additional carbon for photosynthesis, thereby affecting nutrient absorption and distribution.MethodsA free-air CO2 enrichment ...
Bo Gao, Bo Gao, Bo Gao, Shaowu Hu, Mingyuan Zhou, Liquan Jing, Yunxia Wang, Jianguo Zhu, Xingxing Sun, Kai Wang, Yulong Wang, Lianxin Yang   +11 more
doaj   +1 more source