Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Совершенствование конструкций сборных отрезных резцов для тяжелых токарных станков [PDF]
, 2012 В данной статье рассмотрены вопросы совершенствования сборных конструкций резцов для тяжелых станков с целью повышения прочности режущей части и повышения жесткости крепления режущих элементов.
Гузенко, В. С. +2 more
core
Finite element simulation of crack propagation and delamination in layered shells due to blade cutting [PDF]
, 2017 open3noThe focus of this work is on the simulation of crack propagation and delamination in layered shells due to cutting by sharp blades. The main features of these type of problems are: material non-linearities, contact, large deformations, fracture ...
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Вплив способу отримання заготовки та його технологічних параметрів на якісні показники породоруйнівних елементів доліт [PDF]
, 2015 Розглядається проблема дослідження впливу на якісні показники робочої частини бурових доліт способу отримання його породоруйнівних елементів. Досліджено породоруйнівні елементи, виготовлені об'ємним армуванням у нерухомі форми, відцентровим армуванням у
Шуляр, І. О.
core
An in-depth investigation of the cutting speed impact on the degraded microstructure of worn PCBN cutting tools [PDF]
, 2011 The impact of an increased cutting speed on the degradation of a low content polycrystalline cubic boron nitride (PCBN) tool material is investigated by advanced microscopy techniques. The locally affected microstructure of worn PCBN cutting tools, after
Andrén, Hans-Olof, Angseryd, Jenny
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Finite Element Studies in Metal Cutting
, 2003 AdvantEdge is a finite element software package that integrates advanced dynamics, thermo-mechanically coupled finite element numerics and material modelling appropriate for machining processes. AdvantEdge allows users to specify the workpiece material, tool geometry and cutting conditions.
openaire +3 more sources
Not only the butterflies: managing ants on road verges to benefit Phengaris (Maculinea) butterflies [PDF]
, 2010 Obligate myrmecophilic butterfly species, such as Phengaris (Maculinea) teleius and P. nausithous, have narrow habitat requirements. Living as a caterpillar in the nests of the ant species Myrmica scabrinodis and M.
Gestel, R., van +3 more
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source