Results 81 to 90 of about 918,916 (305)

Совершенствование конструкций сборных отрезных резцов для тяжелых токарных станков [PDF]

, 2012
В данной статье рассмотрены вопросы совершенствования сборных конструкций резцов для тяжелых станков с целью повышения прочности режущей части и повышения жесткости крепления режущих элементов.
Гузенко, В. С., Миранцов, С. Л., Мироненко, Е. В.   +2 more
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Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Hybrid FE/ANN and LPR approach for the inverse identification of material parameters from cutting tests [PDF]

, 2011
Accuracy of numerical models based in finite elements (FE), extensively used for simulation of cutting processes, depends strongly on the identification of proper material parameters.
González-Farias, Isabel, Miguélez, Henar, Muñoz-Sánchez, Ana, Xoldani, Xavier   +3 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Finite Element Studies in Metal Cutting

, 2003
AdvantEdge is a finite element software package that integrates advanced dynamics, thermo-mechanically coupled finite element numerics and material modelling appropriate for machining processes. AdvantEdge allows users to specify the workpiece material, tool geometry and cutting conditions.
openaire   +3 more sources

Selective wear of cuttings elements of working organs of tillage machines with realization of self-sharpening effect [PDF]

, 2013
The clause of strengthening of cuttings elements is conditioning and realization of such selforganization process as a self-sharpening. Sharpening of horizontal and vertical cuttings elements of working organs of tillage machines (CE WOTM) is considered ...
Aulin, V., Zamota, T., Аулін, В. В.   +2 more
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Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Technology for preparation of thermal elements of SbBiTe alloys for thermoelectric coolers

Moldavian Journal of the Physical Sciences, 2005
An improved technology for treatment of thermal elements of SbBiTe alloys is given. Optimal technological regimes for their cutting, mechanical and chemical polishing are found.
Meglei, Dragoş, Rusu, Anton, Canţer, Valeriu, Dîntu, Maria   +3 more
doaj  

Directional cohesive elements for blade cutting simulations of layered shells [PDF]

, 2016
The blade cutting of thin layered shell involves three small geometrical scales, the scale of layer thicknesses, the scale of blade radius of curvature, the scale of fracture and delamination process zones, which need be resolved when a numerical ...
Confalonieri, Federica, Ghisi, ALDO FRANCESCO, Mirzapour, Jamil, Perego, Umberto   +3 more
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