Results 131 to 140 of about 401,853 (305)

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Optimization Design and Analysis of Drilling Cutting Removing Device Based on CFD Simulation

Shiyou jixie, 2016
To comprehensively and accurately analyze the drilling fluid flow field around cutting removing device, so that to provide necessary technical support for cutting removing structure optimization,the drilling fluid flow field around cutting removing ...
Pei Junfeng, Wang Bing, Shen Jianzhong, Cao Jianshan   +3 more
doaj  

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Numerical Simulation of Downhole Particle Flow in Horizontal Well with PDC Bit

Shiyou jixie, 2019
In the deep shale gas horizontal well drilling, the low cutting carrying efficiency often lead to the problem of bit ball. To address the problem, the CFD-DEM coupling method is used to simulate the horizontal well flow field between PDC bit and ...
Kuang Yuchun, Zhang Rui, Luo Jinwu, Zhu Guanghui   +3 more
doaj  

Influence of water in the MQL technique in the grinding of steel AISI 4340 using CBN wheels

REM: International Engineering Journal
Usually, machining employs cooling methods to avoid high temperatures. In most cases, the cutting fluid is applied with high flow and low pressures. This technique consumes a large amount of cutting fluid that causes serious problems in the environment ...
Bruno Kenta Sato, Alan Rodrigo de Sales, José Claudio Lopes, Luiz Eduardo de Angelo Sanchez, Hamilton Jose de Mello, Paulo Roberto de Aguiar, Eduardo Carlos Bianchi   +6 more
doaj   +1 more source

Экспериментальные исследования эффективности масляной СОТС с присадкой наноглинистых минералов листовой структуры [PDF]

, 2013
В статье приведены результаты экспериментальных испытаний эффективности масляных СОТС с присадкой наноглинистых минералов. Показаны результаты влияния присадок на основе наноглинистых минералов листовой структуры к масляным СОТС на осевую силу и крутящий
Абдулгазис, Д. У., Абдулгазис, У. А., Меметов, С. Р., Умеров, Э. Д., Ягьяев, Э. Э.   +4 more
core  

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Design of pulse jet coolant delivery system for minimal quantity lubricant (IP MQL) operation [PDF]

, 2012
Minimum quantity lubrication (MQL) machining is one of the promising solutions to the requirement for reducing cutting fluid consumption. The work here describes MQL machining in a range of lubricant consumption of 2.0-2.355ml/s, which is between 10 ...
Sapian, Nik Fazli
core