Results 71 to 80 of about 54,574 (258)

INFLUENCE OF CUTTING INSERTS IN MACHINING Al-Si ALLOY-BASED METAL MATRIX COMPOSITES [PDF]

Proceedings on Engineering Sciences
To better comprehend the machinability studies during MMCs, the effect of cutting tool while machining MMCs, the cutting forces that induce and importantly the influence of cutting tool were carried out.
Sudheer Reddy J , Vikram Kedambadi Vasu
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Study of the System of Forces Acting on the Cutter-Oscillator Under Conditions of Turning With Vibration

Shock and Vibration
This paper investigates the forces acting on a cutter-oscillator during free longitudinal orthogonal turning under regenerative self-oscillation conditions.
Pavlo Tryshyn, Serhiy Dyadya, Olena Kozlova   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Effects of machining parameters, ultrasonic vibrations and cooling conditions on cutting forces and tool wear in meso scale ultrasonic vibrations assisted end-milling (UVAEM) of Ti–6Al–4V under dry, flooded, MQL and cryogenic environments – A statistical analysis

Journal of Materials Research and Technology
Ti–6Al–4V, an alloy of titanium has recently gained focus of research to overcome its machinability challenges. Miniaturization in devices has forced a shift towards micro and meso-scale machining.
Adil Rauf, Muhammad Ali Khan, Syed Husain Imran Jaffery, Shahid Ikramullah Butt   +3 more
doaj   +1 more source

Some Effects of the Cutting Fluid on Cutting Force

Journal of the Japan Society of Precision Engineering, 1966
各種の組成を有する切削油剤を用いて, 切削油剤の潤滑効果と冷却効果が, 切削抵抗に及ぼす影響を調べた。超硬バイトによる車軸鋼の切削の場合につき, 普通鋼の高温における機械的性質の変化を考慮に入れて考察した。またそれらに関連して, 切削油剤の作用について, 定性的に一般的考察をした。1) 削り速度20m/min～40m/minにおいては, いずれの切削油剤も有効であるが, 中でも, 極圧潤滑性に富むものの方が, 冷却性に富むものより有効である。水だけでも明らかに切削抵抗を軽減する作用はあるが, その変動係数は比較的大きく, 特に, 削り速度20m/minの場合には, 乾切削の場合よりも大きい。2) 削り速度40m/min以上においては, 塩素系添加剤のものは効果を失い, かえって切削抵抗は高くなる ...
Ryozo FURUICHI, Kentaro TAMAMURA
openaire   +2 more sources