Results 61 to 70 of about 53,977 (258)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Evaluation of Cutting Forces and Temperatures in Micro-Milling of NiTi Alloys Using Finite Element Modeling

Журнал інженерних наук
Today, micro-milling of NiTi alloys is used to manufacture precision mechanisms, instrumentation, space technology, micro-electro-mechanical systems, biomedical devices, and implants. It is becoming increasingly widespread.
Nataliia Balytska, Oleh Tomashevskyi, Valentina Shadura   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The Investigation of The Effect of Cryogenic Processed PVD and CVD Coated Cutting Tools on Machinability in Turning on Hastelloy X Super Alloy

Gazi Üniversitesi Fen Bilimleri Dergisi, 2017
Super alloys are alloys which has the resistance of high temperatures. In addition to that, super alloys are widely used in aerospace, aviation industries, also in gas turbines because of their high creep strength and high corrosion resistance.
Gültekin UZUN, Selçuk YAGMUR, İhsan KORKUT, Ulvi ŞEKER   +3 more
doaj  

Machinability analysis on helical milling of carbon fiber reinforced polymer

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2015
In the helical milling process, a rotating tool traverses a helical trajectory to generate a hole. In order to investigate the cutting state in helical milling of carbon fiber reinforced polymer(CFRP), experiments were conducted with unidirectional and ...
Haiyan WANG, Xuda QIN, Hao LI
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Measurement of Wood Cutting Forces during Bandsawing Using Piezoelectric Dynamometer

Drvna Industrija, 2016
Optimization of wood cutting conditions can decrease the cutting forces, which directly relates to the energy consumption. The aim of this study was to measure cutting force components in bandsaw processing of green oak and beech wood at 90°-90° cutting ...
Payam Moradpour, Frieder Scholz, Kazem Doosthoseini, Asghar Tarmian   +3 more
doaj   +1 more source

Predictive Cutting Force Model and Cutting Force Chart for Milling with Cutter Axis Inclination

International Journal of Automation Technology, 2013
A force model for milling with cutter axis inclination is presented. The model predicts the cutting force and chip flow direction. Three-dimensional chip flow is interpreted as a piling up of the orthogonal cuttings in the planes containing the cutting velocities and the chip flow velocities in the inclined coordinate system with a ball end mill.
Takashi Matsumura, Motohiro Shimada, Kazunari Teramoto, Eiji Usui   +3 more
openaire   +1 more source