Results 121 to 130 of about 1,450,296 (288)

Online Tool Wear Monitoring by the Analysis of Cutting Forces in Transient State for Dry Machining of Ti6Al4V Alloy

Metals, 2019
In this work, the analysis of the cutting speed and feed rate influence on tool wear and cutting forces in Ti6Al4V alloy dry machining is presented. The study has been focused on the machining in a transient state.
Yezika Sánchez Hernández, F. Javier Trujillo Vilches, Carolina Bermudo Gamboa, Lorenzo Sevilla Hurtado   +3 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Impact of cutting forces on surface quality in finish face milling of compacted graphite iron with CBN and nitride ceramic tools

Технічна інженерія
The article presents the results of studies to determine the influence of cutting forces on the quality parameters of machined surfaces as a result of finishing face milling of products made of compacted graphite cast iron (CGI) using round cutting ...
S.I. Radkevych
doaj   +1 more source

Influence of Cutting Interactions on Cutting Force of a Pick

AASRI Procedia, 2012
Abstract Various mechanical excavators have been used for rock cutting. The cutting drum of an excavation machine normally consists of a large number of cutting picks. Accurate calculation of cutting force on individual picks is important to machine design and control. In rock cutting, cuts between picks can interact with each other.
Sun, Yong, Li, X.S.
openaire   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Experimental investigation of hydrodynamics of melt layer during laser cutting of steel [PDF]

, 2011
In laser cutting process, understanding of hydrodynamics of melt layer is significant, because it is an important factor which controls the final quality. In this work, we observed hydrodynamics of melt layer on kerf front in the case of laser cutting of
Remy Fabbro, Koji Hirano, FABBRO, Rémy, HIRANO, Koji   +3 more
core   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Cutting Forces in basic and real life wood machining processes review, COST Action E35 2004-2008: Wood machining - Micromechanics and fracture [PDF]

, 2009
The data available in the literature concerning wood cutting forces permit to build models or to simulate the main wood machining processes (milling, sawing, peeling etc.). This approach contributes to a better understanding of formation of wood surfaces
MARCHAL, Rémy, MOTHE, Frédéric, DENAUD, Louis, BLERON, Laurent, Denaud, Louis-Etienne, THIBAUT, Bernard   +5 more
core  

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source