The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Improving the finishing face milling process of flat surfaces of small width parts
Технічна інженерія, 2021 Face mills equipped with superhard materials find more and more wide application at finishing of high hardness materials. These tools fully reveal the potential at high-speed processing.
H.M. , O.A. , N.O. , L.Ye.
doaj +1 more source
Friction Analysis on Scratch Deformation Modes of Visco-Elastic-Plastic Materials [PDF]
, 2012 Understanding of abrasion resistance and associated surfaces deformation mechanisms is of primary importance in materials engineering and design. Instrumented scratch testing has proven to be a useful tool for characterizing the abrasion resistance of ...
Budi , Setiyana +3 more
core
Surface roughness variation of thin wall milling, related to modal interactions [PDF]
, 2008 High-speed milling operations of thin walls are often limited by the so-called regenerative effect that causes poor surface finish. The aim of this paper is to examine the link between chatter instability and surface roughness evolution for thin wall ...
Assouline +21 more
core +4 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Design development of machine shop area for the cover KS6-57.017 manufacture including the study of the cutter micro geometrical deviations in cutting process by finite elements method [PDF]
, 2019 The thesis develops the design of machine shop area for manufacturing the cover and researching the deviations of micro geometrical parameters during the cutting process by finite elements methodCONTENTS INTRODUCTION 1. GENERAL-TECHNICAL CHAPTER 1.
Adusei, Ebenezer +1 more
core
Three evolutionary paths for magnetar oscillations [PDF]
, 2014 Quasi-periodic oscillations have been seen in the light curves following several magnetar giant flares. These oscillations are of great interest as they probably provide our first ever view of the normal modes of oscillation of neutron stars.
Glampedakis, K., Jones, D. I.
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Аналіз зв'язків режимів різання та попереднього зміцнення твердого сплаву з інтегральним енергетичним критерієм при чистовому точінні сталей [PDF]
, 2010 У статті представлені основні теоретичні підходи до аналізу зв'язків інтегрального енергетичного критерію процесу різання при чистовій обробці сталей гострінням твердосплавним інструментом з режимами різання й попереднього заміщення твердого сплаву.In ...
Калініченко, В. В. +1 more
core