Results 61 to 70 of about 1,505,269 (297)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Evalaution and optimization of laser cutting parameters for plywood materials [PDF]

, 2013
Laser process parameters influence greatly the width of kerfs and quality of the cut edges. This article reports experiments on the laser plywood-cutting performance of a CW 1.5 kW CO2¬ Rofin laser, based on design of experiments (DOE).
Alrashed, K., Olabi, Abdul-Ghani, Rossini, Nicola, Eltawahni, Hayat, Dassisti, Michele, Aldaham, T., Benyounis, Khaled, Olabi AG, Eltawahni HA, Rossini NS, Aldaham, TA, Benyounis KY, Alrashed, K   +12 more
core   +2 more sources

A model of lathe dynamic system when cutting hard-to-work materials

Известия высших учебных заведений. Поволжский регион:Технические науки
Background. Ensuring the surface quality of critical products of aviation equipment, chemical, power engineering, transport systems for various purposes presents certain requirements for the equipment on which surface formation is carried out.
A.A. Ignat'ev, T.G. Nasad, V.A. Dobryakov, V.A. Revyakin   +3 more
doaj   +1 more source

Distribution of profile and area roughness parameters by the location of the analyzed area on the milled surfaces of titanium alloy workpieces

Технічна інженерія
Surface roughness affects the performance and service life of parts. Understanding the differences between the profile and area methods of determining surface roughness allows obtaining more data for analyzing the texture of machined surfaces.
D.S. Bondar, N.O. Balytska
doaj   +1 more source

Effect of wedge blade direction on cutting characteristics of anisotropic polyethylene terephthalate film

Nihon Kikai Gakkai ronbunshu, 2018
In this paper, we aim to clarify the effect of cutting direction on the cutting characteristics of polyethylene terephthalate (PET) film with mechanical anisotropic properties during the wedge indentation process. In order to reveal the difference in the
Satoshi KANEKO, Shigeru NAGASAWA
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Machining Unidirectional Composites using Single-Point Tools: Analysis of Cutting Forces, Chip Formation and Surface Integrity [PDF]

, 2015
The need for high quality machining of composite materials is rising due to the increased utilisation of these materials across several applications. This paper presents experimental findings of orthogonal cutting of unidirectional glass fibre reinforced
Kahwash, Fadi, Maheri, A., Shyha, Islam, Kahwash, F., Shyha, I., Maheri, Alireza   +5 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

DETAILS’ REPAIR OF CONSTRUCTION AND ROAD MACHINES: FLUCTUATIONS’ MODELLING

Вестник СибАДИ, 2019
Introduction. Hole details are quite widely used in structures of construction and road machines. The specialists apply boring for draft, semi-fair, and in some cases for fair processing of such surfaces.
V. E. Ovsyannikov, V. I. Vasilyev
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source