Results 61 to 70 of about 42,092 (305)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Improvement of Rock Cutting Performance through Two-Pass Abrasive Waterjet Cutting

, 2022
Abrasive waterjet (AWJ) has been widely used for the cutting of hard materials such as rocks. The AWJ cutting of rocks has been well documented in the relevant literature. In these studies, one-pass cutting is employed as the cutting mode.
Mohammad Amiri, Gokhan Aydin, Izzet Karakurt, Serkan Kaya   +3 more
core   +1 more source

Distribution of profile and area roughness parameters by the location of the analyzed area on the milled surfaces of titanium alloy workpieces

Технічна інженерія
Surface roughness affects the performance and service life of parts. Understanding the differences between the profile and area methods of determining surface roughness allows obtaining more data for analyzing the texture of machined surfaces.
D.S. Bondar, N.O. Balytska
doaj   +1 more source

Effect of Needle Milling Modes on Machining Productivity

Наука и техника, 2003
The paper presents results of experimental research pertaining to effect of needle milling modes on productivity.It has been ascertained that rates of cutting Vt tension i and micro cutting tool sweep L make an effect on machining productivity.It is ...
I. L. Barshaj
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Determination of chatter-free cutting mode in end milling [PDF]

Chatter accompanies the cutting process and is the main obstacle to achieving precision and productivity in milling operations. To reduce the amplitude of vibrations, it was proposed to use a stability lobes diagram (SLD) when assigning cutting modes ...
Serhii Sapon, Fedorynenko, D.Y., Maksim Sikailo, Dmytro Fedorynenko, Oleksandr Okhrimenko, Sapon, S.P., Sikailo, M.O., Petrakov, Y.V., Yuri Petrakov, Ohrimenko, O.A.   +9 more
core   +1 more source

Effect of wedge blade direction on cutting characteristics of anisotropic polyethylene terephthalate film

Nihon Kikai Gakkai ronbunshu, 2018
In this paper, we aim to clarify the effect of cutting direction on the cutting characteristics of polyethylene terephthalate (PET) film with mechanical anisotropic properties during the wedge indentation process. In order to reveal the difference in the
Satoshi KANEKO, Shigeru NAGASAWA
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of cutting modes and tool wear on the microhardness of the surface layer after face milling of structural and stainless steels

The quality of the surface layer of the parts directly affects the life cycle of these parts within machine components. The required surface quality of parts can be secured when keeping a certain operational sequence.
Popov Alexey, Babak Sergei
core   +1 more source