AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
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Frontier Materials & TechnologiesThe paper presents the results of the study of the end milling temperature of low-alloy steel depending on the cutting modes and the type of crystalline structure. The experiment was carried out on a PROMA FHV-50PD universal milling machine.
Dmitry A. Rastorguev +2 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
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DETAILS’ REPAIR OF CONSTRUCTION AND ROAD MACHINES: FLUCTUATIONS’ MODELLING
Вестник СибАДИ, 2019 Introduction. Hole details are quite widely used in structures of construction and road machines. The specialists apply boring for draft, semi-fair, and in some cases for fair processing of such surfaces.
V. E. Ovsyannikov, V. I. Vasilyev
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Использование современных инструментальных материалов при механической обработке резанием износостойкого чугуна ИЧ210Х30Г3 [PDF]
, 2013 В работе приведены результаты экспериментального исследования механической обработки резанием заготовок из износостойкого чугуна с повышенной твердостью. Предлагается использовать современные инструментальные сплавы.
Дядюра, К. О., Юнак, А. С.
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Simulation of a finishing operation : milling of a turbine blade and influence of damping [PDF]
, 2012 Milling is used to create very complex geometries and thin parts, such as turbine blades. Irreversible geometric defects may appear during finishing operations when a high surface quality is expected.
BALMES, Etienne +4 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
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Design development of machine shop area for the cover KS6-57.017 manufacture including the study of the cutter micro geometrical deviations in cutting process by finite elements method [PDF]
, 2019 The thesis develops the design of machine shop area for manufacturing the cover and researching the deviations of micro geometrical parameters during the cutting process by finite elements methodCONTENTS INTRODUCTION 1. GENERAL-TECHNICAL CHAPTER 1.
Adusei, Ebenezer +1 more
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Selection of design and operational parameters in spindle-holder-tool assemblies for maximum chatter stability by using a new analytical model [PDF]
, 2007 In this paper, using the analytical model developed by the authors, the effects of certain system design and operational parameters on the tool point FRF, thus on the chatter stability are studied.
Budak, Erhan +4 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
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