Results 81 to 90 of about 42,092 (305)

Experiment on Conical Pick Cutting Rock Material Assisted with Front and Rear Water Jet

Advances in Materials Science and Engineering, 2015
Conical picks are one kind of cutting tools widely used in engineering machinery. In the process of rock breaking, the conical pick bears great cutting force and wear. To solve the problem, a new method, conical pick assisted with high pressure water jet,
Xiaohui Liu, Songyong Liu, Lie Li, Xinxia Cui   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The study of end milling temperature of low-alloy steel in coarse-grained and ultrafine-grained states

Frontier Materials & Technologies
The paper presents the results of the study of the end milling temperature of low-alloy steel depending on the cutting modes and the type of crystalline structure. The experiment was carried out on a PROMA FHV-50PD universal milling machine.
Dmitry A. Rastorguev, Aleksandr A. Sevastyanov, Gennady V. Klevtsov   +2 more
doaj   +1 more source

A rotary centrifugal machining of replaceable multi-faceted cutting tool inserts

Известия высших учебных заведений. Поволжский регион:Технические науки, 2021
Background. The object of the research is replaceable multi-faceted carbide tool inserts with rounded cutting edges to increase their strength. The subject of the research is the operation of centrifugal-rotary processing for rounding the cutting edges
A.V. Lipov, N.N. Nyrkov, V.A. Lipov
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Modelling and mechanical characteristics of PDC cutter-rock interaction by combining mixed fragmentation modes with dynamic rock strength

Petroleum
Polycrystalline diamond compact (PDC) bit is one of the most widely used drill bits for improving the rate of penetration in deep oil and gas well and geothermal well.
Guangjian Dong, Ping Chen, Xudong Wang, Jianhong Fu, Yingxin Yang   +4 more
doaj   +1 more source

Simulation models of vibrations at holes boring factored in the technological system’s variable rigidity

Trudy Odesskogo Politehničeskogo Universiteta, 2014
At elongated holes boring several imperfections can occur, namely, the surface waviness and shape inaccuracies in the axial section. This research purpose is to establish the regularities of such imperfections formation depending on the technological ...
Boris О. Tkachenko, Аnna V. Balaniuk
doaj   +1 more source

OPTIMIZATION OF CUTTING MODES AND OPTIMALITY CRITERIA

, 2023
The work considers the optimization model of the machining process. Optimi‐zation criteria and objective functions used in calculations are given. Keywords: optimization of cutting modes, optimization criteria, cutting modes, optimal parameters 
Bohdanov, Oleksandr, Zakharov, Oleksandr, Mohylchenko, Nikita   +2 more
openaire   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source