Results 81 to 90 of about 1,505,269 (297)

Portrait of Rex Nan Kivell aged 30, London, 1930 [picture] /

, 1930
Title devised by catalgouer from inscription.; Inscriptions: "Fenwick Cutting London"--Below image; "Print 1975/3 Item 11805; RNK at age of 30 when he was collecting Australiana"--In ink and pencil on verso.; Condition: Faded, yellowing, silvering, tears.
Cutting, Fenwick.
core  

Multi-criterion optimization of cutting modes at profiled surface finish turning under conditions of variability in limitations in force

, 2017
The paper reports the results in investigations of cutting parameter variability at profiled surfaces turning. The procedure of the multi-criterion optimization of profiled surfaces turning modes taking into account of variability in the limitations in ...
Irina Petryaeva, Т. Ивченко, A. Mikhaylov, А. Михайлов, T. Ivchenko, Ирина Петряева   +5 more
core   +1 more source

Simulation models of vibrations at holes boring factored in the technological system’s variable rigidity

Trudy Odesskogo Politehničeskogo Universiteta, 2014
At elongated holes boring several imperfections can occur, namely, the surface waviness and shape inaccuracies in the axial section. This research purpose is to establish the regularities of such imperfections formation depending on the technological ...
Boris О. Tkachenko, Аnna V. Balaniuk
doaj   +1 more source

A rotary centrifugal machining of replaceable multi-faceted cutting tool inserts

Известия высших учебных заведений. Поволжский регион:Технические науки, 2021
Background. The object of the research is replaceable multi-faceted carbide tool inserts with rounded cutting edges to increase their strength. The subject of the research is the operation of centrifugal-rotary processing for rounding the cutting edges
A.V. Lipov, N.N. Nyrkov, V.A. Lipov
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A predictive model for the cutting force in wood machining developed using mechanical properties [PDF]

, 2012
In this study a number of work piece variations were evaluated whilst limiting the cutting conditions. Eight wood species controlled at four moisture levels were machined along and across the wood grain.
Andrew Naylor,, Perera, Noel, Emil Clahr, Noel Perera,, Naylor, Andrew, Hackney, Philip, Phil Hackney,, Clahr, Emil   +7 more
core   +1 more source

Achieving high quality surface of laminated glass-reinforced plastics during milling

MATEC Web of Conferences, 2018
Milling is one of the most common ways of workpiece machining, but obtaining a high quality surface of laminated composite materials is difficult due to their layered structure, high strength characteristics and low heat conductivity.
Rychkov Daniel, Lobanov Dmitry, Kuznetsov Aleksey   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source