Results 81 to 90 of about 1,483,890 (296)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Trudy Odesskogo Politehničeskogo Universiteta, 2014 At elongated holes boring several imperfections can occur, namely, the surface waviness and shape inaccuracies in the axial section. This research purpose is to establish the regularities of such imperfections formation depending on the technological ...
Boris О. Tkachenko, Аnna V. Balaniuk
doaj +1 more source
A rotary centrifugal machining of replaceable multi-faceted cutting tool inserts
Известия высших учебных заведений. Поволжский регион:Технические науки, 2021 Background. The object of the research is replaceable multi-faceted carbide tool inserts with rounded cutting edges to increase their strength. The subject of the research is the operation of centrifugal-rotary processing for rounding the cutting edges
A.V. Lipov, N.N. Nyrkov, V.A. Lipov
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Design and analysis of a piezoelectric film embedded smart cutting tool [PDF]
, 2013 This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2012 Institution of Mechanical Engineers.The condition of a cutting tool is an important factor for manufacturing processes.
Cheng, K, Rakowski, R
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Achieving high quality surface of laminated glass-reinforced plastics during milling
MATEC Web of Conferences, 2018 Milling is one of the most common ways of workpiece machining, but obtaining a high quality surface of laminated composite materials is difficult due to their layered structure, high strength characteristics and low heat conductivity.
Rychkov Daniel +2 more
doaj +1 more source
INVESTIGATIONS OF LASER CUTTING MODES ON THE QUALITY OF DIFFERENT CUT PARAMETERS
UNITECH – SELECTED PAPERSThis paper is a review article that details the parameters of laser cutting on the quality of the cut, considered as a critical factor of performance, aesthetics and functionality. For certain gauge sizes, two main thicknesses of low carbon steel sheet are considered in more detail in terms of tolerance accuracy.
Viktor Georgiev +2 more
openaire +1 more source
A new approach of high speed cutting modelling: SPH method [PDF]
, 2006 The purpose of this study is to introduce a new approach of high speed cutting numerical modelling. A lagrangian Smoothed Particle Hydrodynamics (SPH) based model is carried out using the Ls-Dyna software.
J. Limido +7 more
core +1 more source