Results 91 to 100 of about 1,505,269 (297)
The interdependence of forces during continuous centerless grinding
Известия высших учебных заведений. Поволжский регион:Технические наукиBackground. A distinctive feature of the implementation of the centerless grinding method is the condition of power closure at the contact points of the treated surface and the elements of the technological system, compliance with which largely ...
P.V. Malinin +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Optimization of Multi-Tool Cutting Modes in Multi-Item Batch Manufacturing System
, 2013 International audienceThe problem of optimization of cutting modes for multiple position machines and transfer lines equipped with multi-spindle heads is considered. Parts of several types are grouped into batches.
Dolgui, Alexandre +2 more
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Cutting a pie is not a piece of cake [PDF]
Is there a division among n players of a cake using n-1 parallel vertical cuts, or of a pie using n radial cuts, that is envy-free (each player thinks he or she receives a largest piece and so does not envy another player) and undominated (there is no ...
Stromquist, Walter +2 more
core
Non-uniform corner cutting [PDF]
, 1988 The convergence of a non-uniform corner cutting process is investigated. It is shown that the limit curve will be differentiable provided the proportions of the corner cuts are kept within appropriate constraints.
Gregory, JA, Qu, R
core +2 more sources
Oral history interview with Lula Cutting [PDF]
, 1983 Oral history interview with Lula Cutting. Her topic is the early history of Eastern Washington University and the Pacific Northwest.
Cutting, Lula
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source