Results 91 to 100 of about 391,162 (302)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Ultrasonic treatment with nickel electroplating combined with oxidation for developing γ-Al2O3 washcoat on Fe-Cr-Al substrate [PDF]

open access: yes, 2012
Fe-Cr-Al is used as metallic support for catalytic converter due to its high thermal conductivity, lower heat capacity, high temperature and mechanical shock resistance. γ-Al2O3 is the most widely used material as washcoat which embedded on metallic
Firdianto, Ade
core  

SPRK: A Low-Cost Stewart Platform For Motion Study In Surgical Robotics

open access: yes, 2017
To simulate body organ motion due to breathing, heart beats, or peristaltic movements, we designed a low-cost, miniaturized SPRK (Stewart Platform Research Kit) to translate and rotate phantom tissue.
Goldberg, Ken   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Оптимизация режимов резания при обработке на тяжелых токарных станках с учетом энергозатрат [PDF]

open access: yes, 2010
Приведены результаты исследования влияния режимов резания токарной обработки на энергозатраты и их выбор с точки зрения минимизации этих расходов.Results of research of influencing the modes of cutting on the expenditures of energy.
Васильева, Л. В.   +3 more
core  

A methodology for the lightweight design of modern transfer machine tools [PDF]

open access: yes, 2018
This paper deals with a modern design approach via finite elements in the definition of the main structural elements (rotary table and working unit) of an innovative family of transfer machine tools. Using the concepts of green design and manufacture, as
Cavalli, Omar   +6 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Achieving high quality surface of laminated glass-reinforced plastics during milling

open access: yesMATEC Web of Conferences, 2018
Milling is one of the most common ways of workpiece machining, but obtaining a high quality surface of laminated composite materials is difficult due to their layered structure, high strength characteristics and low heat conductivity.
Rychkov Daniel   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

The interdependence of forces during continuous centerless grinding

open access: yesИзвестия высших учебных заведений. Поволжский регион:Технические науки
Background. A distinctive feature of the implementation of the centerless grinding method is the condition of power closure at the contact points of the treated surface and the elements of the technological system, compliance with which largely ...
P.V. Malinin   +3 more
doaj   +1 more source

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