Results 91 to 100 of about 42,092 (305)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Achieving high quality surface of laminated glass-reinforced plastics during milling

MATEC Web of Conferences, 2018
Milling is one of the most common ways of workpiece machining, but obtaining a high quality surface of laminated composite materials is difficult due to their layered structure, high strength characteristics and low heat conductivity.
Rychkov Daniel, Lobanov Dmitry, Kuznetsov Aleksey   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Experimental comparison between material stirring in friction stir welding and material removal modes in orthogonal cutting

, 2021
The tool-workpiece interaction in friction stir welding represents a critical issue. It is responsible for the final quality of the joint and the thermo-mechanical phenomena that develop during the process. Unfortunately, this interaction is continuously
Danilo Ambrosio
core   +1 more source

The interdependence of forces during continuous centerless grinding

Известия высших учебных заведений. Поволжский регион:Технические науки
Background. A distinctive feature of the implementation of the centerless grinding method is the condition of power closure at the contact points of the treated surface and the elements of the technological system, compliance with which largely ...
P.V. Malinin, P.Yu. Bochkarev, I.I. Artemov, M.O. Goncharov   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Optimization of Cutting Modes During Sustainable Machining of Products Based on Economic Criteria

The sustainable manufacturing and machining concept using functionally-oriented technologies involves design and technological, economic, social, and environmental dimensions.
Kuk A., Attanasio A., Cocca P., Kusyi Y., Kostiuk O.   +4 more
core   +1 more source

Investigation of the wear and failure modes of surface engineered multipoint cutting tools [PDF]

, 1992
Most of the studies todate into the wear mechanisms associated with cutting tools have been undertaken on single point tools which invariably operate under conditions of high speed and stress.
Fleming, Martin G
core  

Multi-criterion optimization of cutting modes at profiled surface finish turning under conditions of variability in limitations in force

, 2017
The paper reports the results in investigations of cutting parameter variability at profiled surfaces turning. The procedure of the multi-criterion optimization of profiled surfaces turning modes taking into account of variability in the limitations in ...
Irina Petryaeva, Т. Ивченко, A. Mikhaylov, А. Михайлов, T. Ivchenko, Ирина Петряева   +5 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source